Microbubble enhanced threshold reductions for tissue damage using high intensity ultrasound

Binh C. Tran, Jongbum Seo, J. Brian Fowlkes, Charles A. Cain

Research output: Contribution to journalConference articlepeer-review

11 Citations (Scopus)


We show that introducing gas filled microbubbles (ultrasound contrast agent) reduces the threshold intensity and requisite duration of a single ultrasound burst for producing observable tissue damage in canine kidneys in-situ. The presence of microbubble contrast agent enhances the effects of acoustic cavitation in producing tissue damage, especially when short duration ultrasound exposures are used. Unlike thermal ablation mechanisms, acoustic cavitation can destroy tissue without heating overlying tissue layers. By developing approaches using the benefits of microbubbles in reducing both threshold intensity and burst duration, acoustic cavitation may become a more predictable and effective mechanism for non-invasive ultrasound surgery.

Original languageEnglish
Pages (from-to)1389-1392
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Publication statusPublished - 2001
Event2001 Ultrasonics Symposium - Atlanta, GA, United States
Duration: 2001 Oct 62001 Oct 10

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics


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