TY - JOUR
T1 - Metabotropic glutamate receptors
T2 - Phosphorylation and receptor signaling
AU - Chul, Hoon Kim
AU - Lee, Jinu
AU - Lee, Jae Youn
AU - Roche, Katherine W.
PY - 2008/1
Y1 - 2008/1
N2 - Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function.
AB - Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function.
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U2 - 10.1002/jnr.21437
DO - 10.1002/jnr.21437
M3 - Review article
C2 - 17663464
AN - SCOPUS:38049084115
SN - 0360-4012
VL - 86
SP - 1
EP - 10
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 1
ER -