Metabolic syndrome clustering patterns and the association with cardiovascular disease among post-menopausal Korean women

You Jung Choi, Gwang Suk Kim, Sang Hui Chu, Kyung Hee Lee, Chang Gi Park, Minsung Sohn

Research output: Contribution to journalArticlepeer-review

Abstract

The metabolic syndrome (MetS) is a group of diseases conceptualized as a clustering of risk factors, with the risks of developing MetS in women varying significantly before and after menopause. This study investigated MetS clustering patterns and their association with cardiovascular disease (CVD) risk among post-menopausal women (n = 2479) using data from the Korean Genome Epidemiology Study. Using latent class analysis, three groups emerged: diabetic (5.6%), hypertensive (35.2%), and low-risk (59.2%). Relative to the low-risk group, the diabetic group demonstrated associations with older age, a family history of chronic disease, an increased Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), an elevated white blood cell (WBC) count, experience with hysterectomy, being a non-drinker, more physical activity, and excessive sleep. The hypertensive group was associated with older age, lower monthly income, a family history of chronic disease, increased HOMA-IR, a higher WBC count, more physical activity, and excessive sleep. The diabetic and hypertensive groups had a significantly higher CVD risk than the low-risk group (diabetic: odds ratio [OR] = 2.41 [1.11, 5.27]; hypertensive: OR = 2.46 [1.33, 4.55]). This study identified potential markers for MetS screening in post-menopausal women, highlighting the need for early intervention and personalized healthcare for middle-aged women to reduce CVD risk following menopause.

Original languageEnglish
Article number22702
JournalScientific reports
Volume14
Issue number1
DOIs
Publication statusPublished - 2024 Dec

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

All Science Journal Classification (ASJC) codes

  • General

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