Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

Ji Hye Jung; Hyun Jung Choi; Yong Sun Maeng; Jung Yeon Choi; Minhyung Kim; Ja Young Kwon; Yong Won Park; Young Myeong Kim; Daehee Hwang; Young Guen Kwon

doi:10.1016/j.bbrc.2010.08.086

Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

Ji Hye Jung, Hyun Jung Choi, Yong Sun Maeng, Jung Yeon Choi, Minhyung Kim, Ja Young Kwon, Yong Won Park, Young Myeong Kim, Daehee Hwang, Young Guen Kwon

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

Original language	English
Pages (from-to)	523-530
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	400
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2010.08.086
Publication status	Published - 2010 Oct 1

Bibliographical note

Funding Information:
This work was supported by a National Research Laboratory grant ( 20100018854 ) and the Korea Biotech R&D Group of Next-generation growth engine project ( 2010K0012733-08A0301-00310 ) from the Ministry of Education and Science Technology, and a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs ( A085136 ), Korea.

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2010.08.086

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title = "Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells",

abstract = "Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.",

author = "Jung, {Ji Hye} and Choi, {Hyun Jung} and Maeng, {Yong Sun} and Choi, {Jung Yeon} and Minhyung Kim and Kwon, {Ja Young} and Park, {Yong Won} and Kim, {Young Myeong} and Daehee Hwang and Kwon, {Young Guen}",

note = "Funding Information: This work was supported by a National Research Laboratory grant ( 20100018854 ) and the Korea Biotech R&D Group of Next-generation growth engine project ( 2010K0012733-08A0301-00310 ) from the Ministry of Education and Science Technology, and a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs ( A085136 ), Korea. ",

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doi = "10.1016/j.bbrc.2010.08.086",

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T1 - Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

AU - Jung, Ji Hye

AU - Choi, Hyun Jung

AU - Maeng, Yong Sun

AU - Choi, Jung Yeon

AU - Kim, Minhyung

AU - Kwon, Ja Young

AU - Park, Yong Won

AU - Kim, Young Myeong

AU - Hwang, Daehee

AU - Kwon, Young Guen

N1 - Funding Information: This work was supported by a National Research Laboratory grant ( 20100018854 ) and the Korea Biotech R&D Group of Next-generation growth engine project ( 2010K0012733-08A0301-00310 ) from the Ministry of Education and Science Technology, and a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs ( A085136 ), Korea.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

AB - Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

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Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

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