Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth

Su Jung Shin; Woocheol Lee; Jae Il Lee; Seung Ho Baek; Kee Yeon Kum; Won Jun Shon; Kwang Shik Bae

doi:10.1016/j.tripleo.2011.04.026

Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth

Su Jung Shin, Woocheol Lee, Jae Il Lee, Seung Ho Baek, Kee Yeon Kum, Won Jun Shon, Kwang Shik Bae

Department of Conservative Dentistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Objective: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. Study design: Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. Results: Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P <.05). Conclusions: This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF.

Original language	English
Pages (from-to)	548-554
Number of pages	7
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Volume	112
Issue number	4
DOIs	https://doi.org/10.1016/j.tripleo.2011.04.026
Publication status	Published - 2011 Oct

All Science Journal Classification (ASJC) codes

Surgery
Oral Surgery
Otorhinolaryngology
Dentistry(all)

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title = "Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth",

abstract = "Objective: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. Study design: Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. Results: Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P <.05). Conclusions: This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF.",

author = "Shin, {Su Jung} and Woocheol Lee and Lee, {Jae Il} and Baek, {Seung Ho} and Kum, {Kee Yeon} and Shon, {Won Jun} and Bae, {Kwang Shik}",

year = "2011",

month = oct,

doi = "10.1016/j.tripleo.2011.04.026",

language = "English",

volume = "112",

pages = "548--554",

journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology",

issn = "1079-2104",

publisher = "Elsevier USA",

number = "4",

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Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth. / Shin, Su Jung; Lee, Woocheol; Lee, Jae Il et al.
In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, Vol. 112, No. 4, 10.2011, p. 548-554.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth

AU - Shin, Su Jung

AU - Lee, Woocheol

AU - Lee, Jae Il

AU - Baek, Seung Ho

AU - Kum, Kee Yeon

AU - Shon, Won Jun

AU - Bae, Kwang Shik

PY - 2011/10

Y1 - 2011/10

N2 - Objective: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. Study design: Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. Results: Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P <.05). Conclusions: This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF.

AB - Objective: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. Study design: Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. Results: Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P <.05). Conclusions: This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF.

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Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth

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