Management of microbial enzymes for biofuels and biogas production by using metagenomic and genome editing approaches

J. Rajesh Banu, Gopalakrishnan Kumar, Indranil Chattopadhyay

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Non-renewable fossil fuels such as bitumen, coal, natural gas, oil shale, and petroleum are depleting over the world owing to unrestricted consumption. Biofuels such as biodiesel, biobutanol, bioethanol, and biogas are considered an eco-friendly and cost-effective alternatives of fossil fuels. For energy sustainability, the production of advanced biofuels is required. The advancement of genetic and metabolic engineering in microbial cells played a significant contribution to biofuels overproduction. Essential approaches such as next-generation sequencing technologies and CRISPR/Cas9-mediated genome editing of microbial cells are required for the mass manufacture of biofuels globally. Advanced “omics” approaches are used to construct effective microorganisms for biofuels manufacturing. A new investigation is required to augment the production of lignocellulosic-based biofuels with minimal use of energy. Advanced areas of metabolic engineering are introduced in the manufacture of biofuels by the use of engineered microbial strains. Genetically modified microorganisms are used for the production of biofuels in large quantities at a low-cost.

Original languageEnglish
Article number429
Journal3 Biotech
Issue number10
Publication statusPublished - 2021 Oct

Bibliographical note

Publisher Copyright:
© 2021, King Abdulaziz City for Science and Technology.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Environmental Science (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)


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