Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells

Jaemoon Yang, Eun Kyung Lim, Eun Sook Lee, Jin Suck Suh, Seungjoo Haam, Yong Min Huh

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed ultrasensitive magnetoplex as a magnetic labeling agent composed of PEGylated MnFe 2O4 nanocrystals (PMNCs) and polycationics (poly-L-lysine, PLL) for efficient labeling of the h- MSCs and monitoring of the transplanted h-MSCs for a long term. PMNCs were prepared by nanoemulsion methods composed of MnFe2O4 nanocrystals (MNCs) and amphiphilic polymers (mPEG-dodecanoic acid). The prepared PMNCs exhibited excellent biocompatibility and their polycationic complexes (PMNCs/ PLL) demonstrated remarkable sensitivity compared with magnetic iron oxide nanoparticles (MION)/PLL or Ferumoxides/PLL. Furthermore, PMNCs demonstrated the potentials for novel diagnostic and therapeutic strategies with potential applications in various biomedical fields.

Original languageEnglish
Pages (from-to)1275-1283
Number of pages9
JournalJournal of Nanoparticle Research
Issue number4
Publication statusPublished - 2010 May

Bibliographical note

Funding Information:
Acknowledgments This study was supported by the Korea Science and Engineering Foundation (KOSEF) (R15-2004-024-00000-0, M10755020001-07N5502-00110, and R01-2006-000-10023-0) and a grant from the National R&D Program for Cancer Control, Korea Ministry of Health and Welfare (0620190-1).

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Chemistry(all)
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics


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