Magnetic Resonance Imaging Parameters for Noninvasive Prediction of Epidermal Growth Factor Receptor Amplification in Isocitrate Dehydrogenase-Wild-Type Lower-Grade Gliomas: A Multicenter Study

Yae Won Park, Ji Eun Park, Sung Soo Ahn, Eui Hyun Kim, Seok Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung Hong Choi, Ho Sung Kim, Seung Koo Lee

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

BACKGROUND: The epidermal growth factor receptor (EGFR) amplification status of isocitrate dehydrogenase-wild-type (IDHwt) lower-grade gliomas (LGGs; grade II/III) is one of the key markers for diagnosing molecular glioblastoma. However, the association between EGFR status and imaging parameters is unclear. OBJECTIVE: To identify noninvasive imaging parameters from diffusion-weighted and dynamic susceptibility contrast imaging for predicting the EGFR amplification status of IDHwt LGGs. METHODS: A total of 86 IDHwt LGG patients with known EGFR amplification status (62 nonamplified and 24 amplified) from 3 tertiary institutions were included. Qualitative and quantitative imaging features, including histogram parameters from apparent diffusion coefficient (ADC), normalized cerebral blood volume (nCBV), and normalized cerebral blood flow (nCBF), were assessed. Univariable and multivariable logistic regression models were constructed. RESULTS: On multivariable analysis, multifocal/multicentric distribution (odds ratio [OR] = 11.77, P =. 006), mean ADC (OR = 0.01, P =. 044), 5th percentile of ADC (OR = 0.01, P =. 046), and 95th percentile of nCBF (OR = 1.24, P =. 031) were independent predictors of EGFR amplification. The diagnostic performance of the model with qualitative imaging parameters increased significantly when quantitative imaging parameters were added, with areas under the curves of 0.81 and 0.93, respectively (P =. 004). CONCLUSION: The presence of multifocal/multicentric distribution patterns, lower mean ADC, lower 5th percentile of ADC, and higher 95th percentile of nCBF may be useful imaging biomarkers for EGFR amplification in IDHwt LGGs. Moreover, quantitative imaging biomarkers may add value to qualitative imaging parameters.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalNeurosurgery
Volume89
Issue number2
DOIs
Publication statusPublished - 2021 Aug 1

Bibliographical note

Publisher Copyright:
© 2021 Congress of Neurological Surgeons.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Surgery

Fingerprint

Dive into the research topics of 'Magnetic Resonance Imaging Parameters for Noninvasive Prediction of Epidermal Growth Factor Receptor Amplification in Isocitrate Dehydrogenase-Wild-Type Lower-Grade Gliomas: A Multicenter Study'. Together they form a unique fingerprint.

Cite this