Abstract
The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of "zinc-containing metal oxide nanoparticle--biologically/chemically active material" in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.
| Original language | English |
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| Patent number | WO2008/127031 |
| Publication status | Published - 2005 Apr 11 |