Machine learning approaches to surrogate multifidelity Growth and Remodeling models for efficient abdominal aortic aneurysmal applications

Zhenxiang Jiang, Jongeun Choi, Seungik Baek

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6 Citations (Scopus)


Computational Growth and Remodeling (G&R) models have been widely used to capture the pathological development of arterial diseases and have shown promise for aiding clinical diagnosis, prognosis prediction, and staging classification. However, due to the high complexity of the arterial adaptation mechanism, high-fidelity arterial G&R simulation usually takes hours or even days, which hinders its application in clinical practice. To remedy this problem, we develop a computationally efficient arterial G&R simulation framework that comprehensively combines the physics-based G&R simulations and data-driven machine learning approaches. The proposed framework greatly enhances the computational efficiency of arterial G&R simulations, thereby enabling more time-consuming arterial applications, including personalized parameter estimation and arterial disease progression prediction. In particular, we achieve significant computational cost reduction mainly through two methods: (1) constructing a Multifidelity Surrogate (MFS) to approximate multifidelity G&R simulations by using a cokriging approach and (2) developing a novel iterative optimization algorithm for personalized parameter estimation. The proposed framework is demonstrated by estimating G&R model parameters and predicting individual aneurysm growth using follow-up CT images of Abdominal Aortic Aneurysms (AAAs) from 21 patients. Results show that the personalized parameters are satisfactorily estimated and the growth of AAAs is predicted within the clinically relevant time frame, i.e., less than 2 h, without a loss of accuracy.

Original languageEnglish
Article number104394
JournalComputers in Biology and Medicine
Publication statusPublished - 2021 Jun

Bibliographical note

Funding Information:
This work has been supported in part by the National Heart, Lung, and Blood Institute of the National Institutes of Health ( R01HL115185 and U01 1HL135842 , Baek), the National Research Foundation of Korea ( NRF ) grant funded by the Korea government ( MSIT ) ( 2018R1A4A1025986 , Choi). This paper has supplementary downloadable material available at provided by the authors.

Publisher Copyright:
© 2021 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Health Informatics


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