M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects

Jang Eun Cho; Sang Nae Cho; Kyung Wha Lee; Seung Kyu Park; Sungae Cho

doi:10.4046/trd.2005.59.3.272

M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects

Jang Eun Cho, Sang Nae Cho, Kyung Wha Lee, Seung Kyu Park, Sungae Cho

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods: Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA_30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results: The results indicate the cytotoxic and IFN-γ immune responses of CD6+T cells specific for thyA_30-38 were induced in BCG vaccinated healthy subjects. Conclusion: The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.

Original language	English
Pages (from-to)	272-278
Number of pages	7
Journal	Tuberculosis and Respiratory Diseases
Volume	59
Issue number	3
DOIs	https://doi.org/10.4046/trd.2005.59.3.272
Publication status	Published - 2005 Sept

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2005.59.3.272

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@article{30ce7ef38a204450960c57741848ec1f,

title = "M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects",

abstract = "Background: The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods: Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results: The results indicate the cytotoxic and IFN-γ immune responses of CD6+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion: The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.",

author = "Cho, {Jang Eun} and Cho, {Sang Nae} and Lee, {Kyung Wha} and Park, {Seung Kyu} and Sungae Cho",

year = "2005",

month = sep,

doi = "10.4046/trd.2005.59.3.272",

language = "English",

volume = "59",

pages = "272--278",

journal = "Tuberculosis and Respiratory Diseases",

issn = "1738-3536",

publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",

number = "3",

}

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T1 - M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects

AU - Cho, Jang Eun

AU - Cho, Sang Nae

AU - Lee, Kyung Wha

AU - Park, Seung Kyu

AU - Cho, Sungae

PY - 2005/9

Y1 - 2005/9

N2 - Background: The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods: Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results: The results indicate the cytotoxic and IFN-γ immune responses of CD6+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion: The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.

AB - Background: The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods: Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results: The results indicate the cytotoxic and IFN-γ immune responses of CD6+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion: The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.

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JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

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M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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