Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells

Ki Hoon Han, Kyung Hee Hong, Jesang Ko, Kyong Suk Rhee, Myeong Ki Hong, Jae Joong Kim, You Ho Kim, Seung Jung Park

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Oxidized low-density lipoprotein (OxLDL) is an inflammatory modulator in the atherosclerotic plaque. We examined the effect of lysophosphatidyleholine (lysoPC), a main phospholipid component of OxLDL, on inflammatory responses in human CD4 T cells. We found that lysoPC dose- and time-dependently increased expression of CXCR4, the chemokine receptor on CD4 T cells. This increase was inhibited by caffeic acid phenethyl ester or SN50, nuclear factor-κB inhibitors, and also by suppression of G2A expression, the specific receptor for lysoPC, using antisense oligonucleotide. lysoPC enhanced CD4 T cell chemotaxis in response to stromal cell-derived factor-1 (SDF-1), the exclusive ligand for CXCR4. lysoPC also enhanced SDF-1-stimulated production of inflammatory cytokines interleukin-2 and interferon-γ by CD4 T cells activated by anti-CD3 immunoglobulin G. In conclusion, this study demonstrates that lysoPC directly modulates inflammatory responses in human CD4 T cells. The data suggest that the presence of lysoPC and SDF-1 in atherosclerotic lesions may trigger inflammatory responses mediated by CD4 T cells, which may play an important role in progression of atherosclerosis.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalJournal of Leukocyte Biology
Issue number1
Publication statusPublished - 2004 Jul

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology


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