@inproceedings{2adb0f0085344bb6b5c1d18b19a9fd11,
title = "Lymphatic capillary invasion assay by a single cell migration chip",
abstract = "We demonstrated a single cell migration chip which can emulate cancer cell invasion in lymphatic capillaries through a migration channel with resistance choke points. Using a hydrodynamic capturing scheme based on the difference in flow resistance, the device allows for positioning single cells at the start of a migration channel. Different sizes of the resistance choke points in the migration channels are investigated to characterize the deformation capability of cells. To verify the migration platform, we used p38γ gene knockdown MDA-MB-231 (breast cancer) cells, which are known to show lower lymphatic metastasis in-vivo in a separate study. The reduction of the invasive ability in lymphatic capillaries was confirmed by the fabricated migration chip.",
author = "Chen, {Yu Chih} and Allen, {Steven G.} and Wu, {Zhi Fen} and Merajver, {Sofia D.} and Euisik Yoon",
year = "2012",
language = "English",
isbn = "9780979806452",
series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
publisher = "Chemical and Biological Microsystems Society",
pages = "968--970",
booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",
}
