Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain

Sung Tae Kim; Jin Woo Chang; Hea Nam Hong; Onyou Hwang

doi:10.1016/j.neulet.2004.02.015

Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain

Sung Tae Kim, Jin Woo Chang, Hea Nam Hong, Onyou Hwang

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells. We report in the present study that BH4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (TH) immunopositive fibers, a decreased amount of TH protein, and decreased dopamine content. Thus, the results of our study further provide evidence that BH4, the molecule endogenously present in the dopaminergic neurons, may participate in the nigrostriatal degeneration as in Parkinson's disease.

Original language	English
Pages (from-to)	69-72
Number of pages	4
Journal	Neuroscience Letters
Volume	359
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2004.02.015
Publication status	Published - 2004 Apr 8

Bibliographical note

Funding Information:
We are grateful to Y.J. Lee, H.J. Choi and S.W. Kim for technical assistance and help in preparation of the manuscript. This work was supported by a Korea Research Foundation Grant (KRF-2002-005-E00003). S.T. Kim was supported in part by the BK21 Life Sciences Program.

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/j.neulet.2004.02.015

Cite this

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title = "Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain",

abstract = "We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells. We report in the present study that BH4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (TH) immunopositive fibers, a decreased amount of TH protein, and decreased dopamine content. Thus, the results of our study further provide evidence that BH4, the molecule endogenously present in the dopaminergic neurons, may participate in the nigrostriatal degeneration as in Parkinson's disease.",

author = "Kim, {Sung Tae} and Chang, {Jin Woo} and Hong, {Hea Nam} and Onyou Hwang",

note = "Funding Information: We are grateful to Y.J. Lee, H.J. Choi and S.W. Kim for technical assistance and help in preparation of the manuscript. This work was supported by a Korea Research Foundation Grant (KRF-2002-005-E00003). S.T. Kim was supported in part by the BK21 Life Sciences Program.",

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doi = "10.1016/j.neulet.2004.02.015",

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AU - Kim, Sung Tae

AU - Chang, Jin Woo

AU - Hong, Hea Nam

AU - Hwang, Onyou

N1 - Funding Information: We are grateful to Y.J. Lee, H.J. Choi and S.W. Kim for technical assistance and help in preparation of the manuscript. This work was supported by a Korea Research Foundation Grant (KRF-2002-005-E00003). S.T. Kim was supported in part by the BK21 Life Sciences Program.

PY - 2004/4/8

Y1 - 2004/4/8

N2 - We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells. We report in the present study that BH4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (TH) immunopositive fibers, a decreased amount of TH protein, and decreased dopamine content. Thus, the results of our study further provide evidence that BH4, the molecule endogenously present in the dopaminergic neurons, may participate in the nigrostriatal degeneration as in Parkinson's disease.

AB - We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells. We report in the present study that BH4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (TH) immunopositive fibers, a decreased amount of TH protein, and decreased dopamine content. Thus, the results of our study further provide evidence that BH4, the molecule endogenously present in the dopaminergic neurons, may participate in the nigrostriatal degeneration as in Parkinson's disease.

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ER -

Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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