Long-term prognosis of short QT interval in Korean patients: a multicenter retrospective cohort study

Dae Young Kim; Jae Sun Uhm; Min Kim; In Soo Kim; Moo Nyun Jin; Hee Tae Yu; Tae Hoon Kim; Jong Youn Kim; Boyoung Joung; Hui Nam Pak; Moon Hyoung Lee

doi:10.1186/s12872-020-01824-3

Long-term prognosis of short QT interval in Korean patients: a multicenter retrospective cohort study

Dae Young Kim, Jae Sun Uhm, Min Kim, In Soo Kim, Moo Nyun Jin, Hee Tae Yu, Tae Hoon Kim, Jong Youn Kim, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study aimed to determine the clinical characteristics and outcomes of SQTI in a Korean population. Methods: Consecutive patients with SQTI from January 1999 to March 2019 in three university hospitals in South Korea were recruited. SQTI was defined as a Bazett’s formula-corrected QT interval (QTc) ≤ 340 ms in serial electrocardiograms. Age- and sex-matched patients with a normal QTc and without overt cardiovascular disease were included in a 1:4 ratio. Clinical and ECG features and outcomes were compared between patients with and without SQTI. Results: 34 patients with SQTI [age, 23.5 (21–30.5) years; 31 male] were followed up for 4.8 (2.0–7.8) years. Early repolarization, tall T wave, and U wave were significantly more frequent in patients with SQTI than in those without SQTI. QT dispersion [44.0 (28.0–73.0) vs. 20.0 (12.0–35.0) ms, P < 0.001] was significantly wider and heart rate [52.0 (47.0–58.0) vs. 70.0 (62.3–84.0)/min, P < 0.001] was significantly slower in patients with SQTI than in those without. Atrial fibrillation (AF, 11.8% vs. 2.2%, P = 0.030) and ventricular arrhythmia (VA)/SCA (8.7% vs. 0%, P = 0.007) were significantly more frequent in patients with SQTI than in those without. SQTI was significantly associated with AF [odds ratio, 5.911; 95% confidence interval, 1.257–27.808; P = 0.025] and VA/SCA. Conclusions: In this subset of Korean population, SQTI was associated with AF and VA/SCA.

Original language	English
Article number	17
Journal	BMC Cardiovascular Disorders
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12872-020-01824-3
Publication status	Published - 2021 Dec

Bibliographical note

Funding Information:
The authors thank Ju-young Park, M.S. and Soyoung Jeon, M.S. in the Biostatistics Collaboration Unit, Yonsei University College of Medicine, for their assistance with the statistical analyses and Kina Hu, M.B.A. of GE Healthcare for her assistance with data collection from MUSETMCardiology Information System. We have previously published the abstract of this article in the Heart Rhythm journal on May, 2020 [16].

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12872-020-01824-3

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@article{bc4e839d475b468881ae3f776af803a9,

title = "Long-term prognosis of short QT interval in Korean patients: a multicenter retrospective cohort study",

abstract = "Background: Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study aimed to determine the clinical characteristics and outcomes of SQTI in a Korean population. Methods: Consecutive patients with SQTI from January 1999 to March 2019 in three university hospitals in South Korea were recruited. SQTI was defined as a Bazett{\textquoteright}s formula-corrected QT interval (QTc) ≤ 340 ms in serial electrocardiograms. Age- and sex-matched patients with a normal QTc and without overt cardiovascular disease were included in a 1:4 ratio. Clinical and ECG features and outcomes were compared between patients with and without SQTI. Results: 34 patients with SQTI [age, 23.5 (21–30.5) years; 31 male] were followed up for 4.8 (2.0–7.8) years. Early repolarization, tall T wave, and U wave were significantly more frequent in patients with SQTI than in those without SQTI. QT dispersion [44.0 (28.0–73.0) vs. 20.0 (12.0–35.0) ms, P < 0.001] was significantly wider and heart rate [52.0 (47.0–58.0) vs. 70.0 (62.3–84.0)/min, P < 0.001] was significantly slower in patients with SQTI than in those without. Atrial fibrillation (AF, 11.8% vs. 2.2%, P = 0.030) and ventricular arrhythmia (VA)/SCA (8.7% vs. 0%, P = 0.007) were significantly more frequent in patients with SQTI than in those without. SQTI was significantly associated with AF [odds ratio, 5.911; 95% confidence interval, 1.257–27.808; P = 0.025] and VA/SCA. Conclusions: In this subset of Korean population, SQTI was associated with AF and VA/SCA.",

author = "Kim, {Dae Young} and Uhm, {Jae Sun} and Min Kim and Kim, {In Soo} and Jin, {Moo Nyun} and Yu, {Hee Tae} and Kim, {Tae Hoon} and Kim, {Jong Youn} and Boyoung Joung and Pak, {Hui Nam} and Lee, {Moon Hyoung}",

note = "Funding Information: The authors thank Ju-young Park, M.S. and Soyoung Jeon, M.S. in the Biostatistics Collaboration Unit, Yonsei University College of Medicine, for their assistance with the statistical analyses and Kina Hu, M.B.A. of GE Healthcare for her assistance with data collection from MUSETMCardiology Information System. We have previously published the abstract of this article in the Heart Rhythm journal on May, 2020 [16]. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s12872-020-01824-3",

language = "English",

volume = "21",

journal = "BMC Cardiovascular Disorders",

issn = "1471-2261",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Long-term prognosis of short QT interval in Korean patients

T2 - a multicenter retrospective cohort study

AU - Kim, Dae Young

AU - Uhm, Jae Sun

AU - Kim, Min

AU - Kim, In Soo

AU - Jin, Moo Nyun

AU - Yu, Hee Tae

AU - Kim, Tae Hoon

AU - Kim, Jong Youn

AU - Joung, Boyoung

AU - Pak, Hui Nam

AU - Lee, Moon Hyoung

N1 - Funding Information: The authors thank Ju-young Park, M.S. and Soyoung Jeon, M.S. in the Biostatistics Collaboration Unit, Yonsei University College of Medicine, for their assistance with the statistical analyses and Kina Hu, M.B.A. of GE Healthcare for her assistance with data collection from MUSETMCardiology Information System. We have previously published the abstract of this article in the Heart Rhythm journal on May, 2020 [16]. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Background: Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study aimed to determine the clinical characteristics and outcomes of SQTI in a Korean population. Methods: Consecutive patients with SQTI from January 1999 to March 2019 in three university hospitals in South Korea were recruited. SQTI was defined as a Bazett’s formula-corrected QT interval (QTc) ≤ 340 ms in serial electrocardiograms. Age- and sex-matched patients with a normal QTc and without overt cardiovascular disease were included in a 1:4 ratio. Clinical and ECG features and outcomes were compared between patients with and without SQTI. Results: 34 patients with SQTI [age, 23.5 (21–30.5) years; 31 male] were followed up for 4.8 (2.0–7.8) years. Early repolarization, tall T wave, and U wave were significantly more frequent in patients with SQTI than in those without SQTI. QT dispersion [44.0 (28.0–73.0) vs. 20.0 (12.0–35.0) ms, P < 0.001] was significantly wider and heart rate [52.0 (47.0–58.0) vs. 70.0 (62.3–84.0)/min, P < 0.001] was significantly slower in patients with SQTI than in those without. Atrial fibrillation (AF, 11.8% vs. 2.2%, P = 0.030) and ventricular arrhythmia (VA)/SCA (8.7% vs. 0%, P = 0.007) were significantly more frequent in patients with SQTI than in those without. SQTI was significantly associated with AF [odds ratio, 5.911; 95% confidence interval, 1.257–27.808; P = 0.025] and VA/SCA. Conclusions: In this subset of Korean population, SQTI was associated with AF and VA/SCA.

AB - Background: Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study aimed to determine the clinical characteristics and outcomes of SQTI in a Korean population. Methods: Consecutive patients with SQTI from January 1999 to March 2019 in three university hospitals in South Korea were recruited. SQTI was defined as a Bazett’s formula-corrected QT interval (QTc) ≤ 340 ms in serial electrocardiograms. Age- and sex-matched patients with a normal QTc and without overt cardiovascular disease were included in a 1:4 ratio. Clinical and ECG features and outcomes were compared between patients with and without SQTI. Results: 34 patients with SQTI [age, 23.5 (21–30.5) years; 31 male] were followed up for 4.8 (2.0–7.8) years. Early repolarization, tall T wave, and U wave were significantly more frequent in patients with SQTI than in those without SQTI. QT dispersion [44.0 (28.0–73.0) vs. 20.0 (12.0–35.0) ms, P < 0.001] was significantly wider and heart rate [52.0 (47.0–58.0) vs. 70.0 (62.3–84.0)/min, P < 0.001] was significantly slower in patients with SQTI than in those without. Atrial fibrillation (AF, 11.8% vs. 2.2%, P = 0.030) and ventricular arrhythmia (VA)/SCA (8.7% vs. 0%, P = 0.007) were significantly more frequent in patients with SQTI than in those without. SQTI was significantly associated with AF [odds ratio, 5.911; 95% confidence interval, 1.257–27.808; P = 0.025] and VA/SCA. Conclusions: In this subset of Korean population, SQTI was associated with AF and VA/SCA.

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U2 - 10.1186/s12872-020-01824-3

DO - 10.1186/s12872-020-01824-3

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SN - 1471-2261

VL - 21

JO - BMC Cardiovascular Disorders

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ER -

Long-term prognosis of short QT interval in Korean patients: a multicenter retrospective cohort study

Abstract

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UN SDGs

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