Long-term outcome of amyotrophic lateral sclerosis in Korean subjects

Mi Ri Suh, Won Ah Choi, Young Chul Choi, Jang Woo Lee, Jung Hwa Hong, Jihyun Park, Seong Woong Kang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective To report the latest long-term outcome of amyotrophic lateral sclerosis (ALS) and to analyze the predictors of prognosis.Methods Subjects who were diagnosed with ALS between January 2005 and December 2009 at a single institute were followed up until death or up to December 2014. Data regarding age, sex, date of onset, date of diagnosis, presence of bulbar symptoms on onset, date of initiation of non-invasive ventilation (NIV), and the date of tracheostomy were collected. Survival was assessed using Kaplan-Meier curves and multivariate analyses of the risk of death were performed using the Cox proportional hazards model. Results Among 212 suspicious subjects, definite ALS was diagnosed in 182 subjects. The survival rate at 3 and 5 years from onset was 61.5% and 40.1%, respectively, and the survival rate at 3 and 5 years post-diagnosis was 49.5% and 24.2%, respectively. Further, 134 patients (134/182, 73.6%) were initiated on NIV, and among them, 90 patients (90/182, 49.5%) underwent tracheostomy. Male gender and onset age of ≥65 years were independent predictors of adverse survival.Conclusion The analysis of long term survival in ALS showed excellent outcomes considering the overall poor prognosis of this disease.

Original languageEnglish
Pages (from-to)1055-1064
Number of pages10
JournalAnnals of Rehabilitation Medicine
Issue number6
Publication statusPublished - 2017 Dec 1

Bibliographical note

Publisher Copyright:
© 2017 by Korean Academy of Rehabilitation Medicine.

All Science Journal Classification (ASJC) codes

  • Rehabilitation


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