Long-term effectiveness and safety of tafluprost, travoprost, and latanoprost in korean patients with primary open-angle glaucoma or normal-tension glaucoma: A multicenter retrospective cohort study (lotus study)

Joon Mo Kim, Kyung Rim Sung, Hwang Ki Kim, Sang Woo Park, Eun Ji Lee, Jin Wook Jeoung, Hae Young Lopilly Park, Jaehong Ahn, Chungkwon Yoo, Chan Yun Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This multicenter retrospective cohort study compared the effectiveness and safety of long-term tafluprost, travoprost, or latanoprost in patients with primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG). Data were extracted from electronic medical records of 300 patients treated with tafluprost, travoprost, or latanoprost for >6 months. Propensity matching for age and sex was used for effectiveness and safety comparisons. The primary endpoint was visual field (VF) progression via mean deviation (MD) slope. Secondary endpoints were change of MD, intra-ocular pressure, pattern standard deviation, VF index, and advanced glaucoma intervention study score. Treatment-related adverse events (AEs) were also compared between groups. Overall, 216 POAG or NTG patients were matched into Match Set 1 (72 patients/group), and 177 NTG-only patients in Match Set 2 (59 patients/group) according to: age (mean: 61, 62 years) and sex (male: 53, 56%). There were no statistically significant between-group differences regarding MD slope (p = 0.413, p = 0.374 in Match Sets 1 and 2, respectively). There were no significant between-group dif-ferences/tendencies regarding secondary endpoints. No AEs were serious, and there were no significant between-group differences regarding reported AEs. In patients with POAG or NTG, long-term tafluprost, travoprost, or latanoprost showed similar effects. All three prostaglandin analogs had good long-term safety profiles.

Original languageEnglish
Article number2717
JournalJournal of Clinical Medicine
Volume10
Issue number12
DOIs
Publication statusPublished - 2021 Jun 2

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • General Medicine

Fingerprint

Dive into the research topics of 'Long-term effectiveness and safety of tafluprost, travoprost, and latanoprost in korean patients with primary open-angle glaucoma or normal-tension glaucoma: A multicenter retrospective cohort study (lotus study)'. Together they form a unique fingerprint.

Cite this