Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on “Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence” by Karner et al. (2019)

Hyun Jung Oh; Jeannie T. Lee

doi:10.1016/j.jmb.2019.11.011

Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on “Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence” by Karner et al. (2019)

Hyun Jung Oh, Jeannie T. Lee

Research output: Contribution to journal › Comment/debate › peer-review

3 Citations (Scopus)

Abstract

The mouse lncRNA Jpx has been shown as an essential regulator in X-chromosome inactivation (XCI). Jpx RNA activates Xist expression through its trans-acting ability to evict CTCF from Xist promoter. Karner et al. (2019) reveals the intriguing finding that human JPX and mouse Jpx are functionally conserved although they have low similarity in the primary sequence and the secondary structure. This study provides an excellent model for studying lncRNA's evolution and epigenetic function.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	Journal of Molecular Biology
Volume	432
Issue number	2
DOIs	https://doi.org/10.1016/j.jmb.2019.11.011
Publication status	Published - 2020 Jan 17

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Molecular Biology

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10.1016/j.jmb.2019.11.011

Cite this

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abstract = "The mouse lncRNA Jpx has been shown as an essential regulator in X-chromosome inactivation (XCI). Jpx RNA activates Xist expression through its trans-acting ability to evict CTCF from Xist promoter. Karner et al. (2019) reveals the intriguing finding that human JPX and mouse Jpx are functionally conserved although they have low similarity in the primary sequence and the secondary structure. This study provides an excellent model for studying lncRNA's evolution and epigenetic function.",

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Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on “Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence” by Karner et al. (2019). / Oh, Hyun Jung; Lee, Jeannie T.
In: Journal of Molecular Biology, Vol. 432, No. 2, 17.01.2020, p. 301-304.

Research output: Contribution to journal › Comment/debate › peer-review

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AU - Lee, Jeannie T.

PY - 2020/1/17

Y1 - 2020/1/17

N2 - The mouse lncRNA Jpx has been shown as an essential regulator in X-chromosome inactivation (XCI). Jpx RNA activates Xist expression through its trans-acting ability to evict CTCF from Xist promoter. Karner et al. (2019) reveals the intriguing finding that human JPX and mouse Jpx are functionally conserved although they have low similarity in the primary sequence and the secondary structure. This study provides an excellent model for studying lncRNA's evolution and epigenetic function.

AB - The mouse lncRNA Jpx has been shown as an essential regulator in X-chromosome inactivation (XCI). Jpx RNA activates Xist expression through its trans-acting ability to evict CTCF from Xist promoter. Karner et al. (2019) reveals the intriguing finding that human JPX and mouse Jpx are functionally conserved although they have low similarity in the primary sequence and the secondary structure. This study provides an excellent model for studying lncRNA's evolution and epigenetic function.

KW - Jpx

KW - LncRNA evolution

KW - Long noncoding RNA

KW - X-chromosome inactivation

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Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on “Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence” by Karner et al. (2019)

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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