Lobophorin Producing Endophytic Streptomyces olivaceus JB1 Associated With Maesa japonica (Thunb.) Moritzi & Zoll.

Soohyun Um, Jaeyoun Lee, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review


In this study, we focused on endophytes of Maesa japonica (Thunb.) Moritzi & Zoll. and the plant-microbe interaction at metabolite levels. We isolated seven endophytes associated with M. japonica (JB1−7), and focused on Streptomyces olivaceus JB1 because of antibacterial activities of its secondary metabolites. We confirmed lobophorin analogs production from the bacterial strain JB1 by using spectroscopic techniques such as NMR, UV, and LC/Q-TOF-MS. In the LC/MS system, thirteen reported lobophorin analogs and twelve unreported analogs were detected. Among metabolites, lobophorin A was clearly detected in the dried foliar residues of M. japonica which implies that JB1 resides in the host and accumulates its secondary metabolites likely interacting with the plant. Antimicrobial activity tests of the secondary metabolites against undesirable contaminants isolated from the external surface of M. japonica supported the host and microbe mutualistic relationship. In the meantime, lobophorin producing Streptomyces spp. were isolated from marine environments such as marine sediments, algae, corals, and sponges. As lobophorin producing Streptomyces is isolated commonly from marine environments, we conducted a saline water stress tolerance test with JB1 showing saline medium does not accelerate the growth of the bacterium.

Original languageEnglish
Article number881253
JournalFrontiers in Microbiology
Publication statusPublished - 2022 Apr 29

Bibliographical note

Funding Information:
We acknowledge financial support from the National Research Foundation of Korea (NRF-2018R1A6A1A03023718 and NRF-2020R1A2C1012632), funded by the Ministry of Education, Science and Technology, South Korea.

Publisher Copyright:
Copyright © 2022 Um, Lee and Kim.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)


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