Liver‐Directed Concurrent Chemoradiotherapy versus Sorafenib in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

Jina Kim, Hwa Kyung Byun, Tae Hyung Kim, Sun Il Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Jinsil Seong

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1 Citation (Scopus)


This study aimed to investigate the efficacy of liver‐directed concurrent chemoradiother-apy (LD‐CCRT) compared with sorafenib in patients with liver‐confined locally advanced hepato-cellular carcinoma (HCC) presenting portal vein tumor thrombosis (PVTT). This single institute retrospective cohort study included patients treated with sorafenib or LD‐CCRT between 2005 and 2016. Patients with extrahepatic disease and those without PVTT were excluded, leaving 28 and 448 patients in the sorafenib and LD‐CCRT groups, respectively. Propensity score matching was performed to balance the differences in clinical features between the two groups. At baseline, the so-rafenib group presented higher incidences of unfavorable clinical features, including type III‐IV PVTT (53.6% vs. 30.6%, p = 0.048) and bilateral disease extent (64.3% vs. 31.5%, p = 0.001), than the LD‐CCRT group. A total of 27 patients from the sorafenib group and 52 patients from the LD‐CCRT group were matched. At a median follow‐up of 73 months, the median overall survival (OS) was 4.3 and 9.8 months in the sorafenib and LD‐CCRT groups, respectively (p = 0.002). Patients with PVTT type II and higher benefited more from LD‐CCRT in terms of OS. The Cox proportional haz-ard model showed that LD‐CCRT was a significant prognostic factor for OS. One patient from the sorafenib group and seven patients from the LD‐CCRT group underwent curative surgical treat-ment. Patients who underwent surgical treatment had significantly longer OS. In conclusion, LD‐ CCRT showed superior survival outcomes to sorafenib in HCC patients with PVTT. LD‐CCRT needs further consideration for its substantial local tumor control that can enable curative surgical treatment in selected patients.

Original languageEnglish
Article number2396
Issue number10
Publication statusPublished - 2022 May 1

Bibliographical note

Funding Information:
Funding: This study was supported by the Dong‐A research fund, grant number 2018‐31‐0904.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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