TY - JOUR
T1 - Liposome fusion induced by pH-sensitive copolymer
T2 - Poly(4-vinyIpyridine-co-N/N-diethylaminoethyl methacrylate)
AU - Park, Jong Sang
AU - Lim, Yong Beom
AU - Kvvon, Young Min
AU - Jeong, Byeongmoon
AU - Choi, Young Hun
AU - Kim, Sung Wan
PY - 1999/7/15
Y1 - 1999/7/15
N2 - Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.
AB - Copolymers of 4-vinylpyridine (4VP) or Af,.ZV'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK value of the two monomers.
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U2 - 10.1002/(sici)1099-0518(19990715)37:14<2305::aid-pola3>3.0.co;2-5
DO - 10.1002/(sici)1099-0518(19990715)37:14<2305::aid-pola3>3.0.co;2-5
M3 - Article
AN - SCOPUS:0032646923
SN - 0887-624X
VL - 37
SP - 2305
EP - 2309
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
IS - 14
ER -