Linear and cyclic poly(2-isopropyl-2-oxazoline)s for fine control of thermoresponsiveness

Yongseok Jung, Joo Ho Kim, Woo Dong Jang

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20 Citations (Scopus)


Linear and cyclic poly(2-isopropyl-2-oxazoline)s (POx)s with the same average molar mass and molar mass distribution were synthesized by living cationic ring-opening polymerization of 2-isopropyl-2-oxazoline (Ox) and a successive intramolecular Cu(I)-catalyzed click reaction. The synthesis of linear poly(2-isopropyl-2-oxazoline) (l-POx) and cyclic poly(2-isopropyl-2-oxazoline) (c-POx) was characterized by 1H NMR, FT-IR, MALDI-TOF-MS and analytical SEC. Both POxs exhibited a sharp thermal transition upon temperature changes in physiological saline (150 mM NaCl) phosphate buffered solution (PBS, 10 mM, pH 7.4). Interestingly, the thermal transition temperature of the c-POx was much higher than that of the l-POx. The large difference of thermal transition temperatures between c-POx and l-POx was utilized for the fine tuning of the thermal transition temperature. By adjusting the mixing ratio of the two polymers, the thermal transition temperatures were varied from 44 to 57 °C.

Original languageEnglish
Pages (from-to)605-612
Number of pages8
JournalEuropean Polymer Journal
Publication statusPublished - 2017 Mar 1

Bibliographical note

Funding Information:
This work was supported by the Mid-Career Researcher Program (2014R1A2A1A10051083) funded by the National Research Foundation (NRF) of Korea.

Publisher Copyright:
© 2016 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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