Lifetime expression of stem cell markers in the uterine endometrium

Nam Hoon Cho, Young Kyu Park, Young Tae Kim, Hyunwon Yang, Sei Kwang Kim

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


Objective: To identify stem cells in uteri from the fetal to the postmenopausal period. Design: Descriptive, controlled study. Setting: Tertiary academic medical center. Patient(s): Forty archived uterine endometrial samples. Intervention(s): Immunohistochemistry with c-kit/CD117, CD34, bcl-2, and Ki67. Main Outcome Measure(s): Immunostaining. Result(s): C-kit/CD117, CD34, bcl-2, and Ki67 were consistently expressed in the stroma of the basalis layer. Bcl-2 was restricted to the fetal uterine endometrium. Conclusion(s): By studying the immunolocalization of stem cell markers (i.e., c-kit, CD34, and bcl-2), we found that stem cells are present continuously in the uterine endometrium from the fetal period. The cells seem to be located mainly in the stroma of the basalis and to be independent of hormonal regulation to avoid cyclic shedding. A small number of latent stem cells dormant in the stroma of the basalis were found to have the potential for mesenchymal differentiation.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalFertility and Sterility
Issue number2
Publication statusPublished - 2004 Feb

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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