Leptin-promoted cilia assembly is critical for normal energy balance

Yu Mi Han, Gil Myoung Kang, Kyunghee Byun, Hyuk Wan Ko, Joon Kim, Mi Seon Shin, Hyun Kyong Kim, So Young Gil, Ji Hee Yu, Bonghee Lee, Min Seon Kim

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


The majority of mammalian cells have nonmotile primary cilia on their surface that act as antenna-like sensory organelles. Genetic defects that result in ciliary dysfunction are associated with obesity in humans and rodents, which suggests that functional cilia are important for controlling energy balance. Here we demonstrated that neuronal cilia lengths were selectively reduced in hypothalami of obese mice with leptin deficiency and leptin resistance. Treatment of N1 hypothalamic neuron cells with leptin stimulated cilia assembly via inhibition of the tumor suppressors PTEN and glycogen synthase kinase 3β(GSK3β). Induction of short cilia in the hypothalamus of adult mice increased food intake and decreased energy expenditure, leading to a positive energy balance. Moreover, mice with short hypothalamic cilia exhibited attenuated anorectic responses to leptin, insulin, and glucose, which indicates that leptin-induced cilia assembly is essential for sensing these satiety signals by hypothalamic neurons. These data suggest that leptin governs the sensitivity of hypothalamic neurons to metabolic signals by controlling the length of the cell's antenna.

Original languageEnglish
Pages (from-to)2193-2197
Number of pages5
JournalJournal of Clinical Investigation
Issue number5
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Leptin-promoted cilia assembly is critical for normal energy balance'. Together they form a unique fingerprint.

Cite this