Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia

Jung Yoon Hee; Yong Choi Jun; Oh Kim Chang; Seon Park Yoon; Soo Kim Myoung; Keun Kim Young; Youn Shin So; Myung Kim June; Goo Song Young

doi:10.3346/jkms.2006.21.6.979

Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia

Jung Yoon Hee, Yong Choi Jun, Oh Kim Chang, Seon Park Yoon, Soo Kim Myoung, Keun Kim Young, Youn Shin So, Myung Kim June, Goo Song Young

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.

Original language	English
Pages (from-to)	979-982
Number of pages	4
Journal	Journal of Korean medical science
Volume	21
Issue number	6
DOIs	https://doi.org/10.3346/jkms.2006.21.6.979
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.3346/jkms.2006.21.6.979

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title = "Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia",

abstract = "Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.",

author = "Hee, {Jung Yoon} and Jun, {Yong Choi} and Chang, {Oh Kim} and Yoon, {Seon Park} and Myoung, {Soo Kim} and Young, {Keun Kim} and So, {Youn Shin} and June, {Myung Kim} and Young, {Goo Song}",

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T1 - Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia

AU - Hee, Jung Yoon

AU - Jun, Yong Choi

AU - Chang, Oh Kim

AU - Yoon, Seon Park

AU - Myoung, Soo Kim

AU - Young, Keun Kim

AU - So, Youn Shin

AU - June, Myung Kim

AU - Young, Goo Song

PY - 2006

Y1 - 2006

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AB - Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.

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Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia

Abstract

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