Label-free detection of zinc oxide nanowire using a graphene wrapping method

Juneseok You, Kuewhan Jang, Sangmyung Lee, Doyeon Bang, Seungjoo Haam, Chang Hwan Choi, Jinsung Park, Sungsoo Na

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Zinc oxide nanowires (ZnO NWs) have been attempted to various applications, such as piezoelectric devices, energy harvesting devices, self-powered nanosensors, and biomedical devices. However, recent reports have shown the toxic effect of ZnO NWs. In this report, we described the detection of ZnO NWs, for the first time using reduced graphene oxide (RGO) wrapping method. By wrapping RGO to ZnO NW (RGO-ZnO NW), we are able to aggregate ZnO NWs and increase the sensing performance. The detection measurement is based on the resonance frequency shift derived from mass variation of RGO-ZnO NW adsorption on the DNA immobilized resonator. The resonator is able to detect ZnO NWs with detection limit of 100ngmL-1 which is 2 order below the fatal toxic concentration of ZnO NWs in Human Monocyte Macrophages (HMMs). Furthermore, the resonator is able to detect ZnO NWs in real tap water, showing the potential as ZnO NWs screening platform in real environmental aqua system.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalBiosensors and Bioelectronics
Publication statusPublished - 2015 Jun 5

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) under Grant nos. NRF-2012-0000785 , NRF-2012-0006646 , NRF-2014R1A2A1A11052389 and NRF-2013R1A1A1058102 which is funded by the Ministry of Science, ICT & Future Planning .

Publisher Copyright:
© 2015 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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