Label-free CMOS DNA quantification with on-chip noise reduction schemes

Seong Jin Kim; Mithun Shenoi; Kyutae Yoo; Jeoyoung Shim; Wonseok Chung; Christopher Ko; Lee Sup Kim; Euisik Yoon

doi:10.1109/SENSOR.2007.4300288

Label-free CMOS DNA quantification with on-chip noise reduction schemes

Seong Jin Kim, Mithun Shenoi, Kyutae Yoo, Jeoyoung Shim, Wonseok Chung, Christopher Ko, Lee Sup Kim, Euisik Yoon

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Citations (Scopus)

Abstract

We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.

Original language	English
Title of host publication	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	947-950
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2007.4300288
Publication status	Published - 2007
Event	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France Duration: 2007 Jun 10 → 2007 Jun 14

Publication series

Name	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
Country/Territory	France
City	Lyon
Period	07/6/10 → 07/6/14

All Science Journal Classification (ASJC) codes

Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/SENSOR.2007.4300288

Cite this

Kim, S. J., Shenoi, M., Yoo, K., Shim, J., Chung, W., Ko, C., Kim, L. S., & Yoon, E. (2007). Label-free CMOS DNA quantification with on-chip noise reduction schemes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 947-950). Article 4300288 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300288

Kim, Seong Jin ; Shenoi, Mithun ; Yoo, Kyutae et al. / Label-free CMOS DNA quantification with on-chip noise reduction schemes. TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. pp. 947-950 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

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title = "Label-free CMOS DNA quantification with on-chip noise reduction schemes",

abstract = "We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.",

author = "Kim, {Seong Jin} and Mithun Shenoi and Kyutae Yoo and Jeoyoung Shim and Wonseok Chung and Christopher Ko and Kim, {Lee Sup} and Euisik Yoon",

year = "2007",

doi = "10.1109/SENSOR.2007.4300288",

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booktitle = "TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems",

note = "4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 ; Conference date: 10-06-2007 Through 14-06-2007",

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Kim, SJ, Shenoi, M, Yoo, K, Shim, J, Chung, W, Ko, C, Kim, LS & Yoon, E 2007, Label-free CMOS DNA quantification with on-chip noise reduction schemes. in TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems., 4300288, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 947-950, 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07, Lyon, France, 07/6/10. https://doi.org/10.1109/SENSOR.2007.4300288

Label-free CMOS DNA quantification with on-chip noise reduction schemes. / Kim, Seong Jin; Shenoi, Mithun; Yoo, Kyutae et al.
TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 947-950 4300288 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Kim, Seong Jin

AU - Shenoi, Mithun

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AU - Shim, Jeoyoung

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AU - Ko, Christopher

AU - Kim, Lee Sup

AU - Yoon, Euisik

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AB - We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.

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Kim SJ, Shenoi M, Yoo K, Shim J, Chung W, Ko C et al. Label-free CMOS DNA quantification with on-chip noise reduction schemes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 947-950. 4300288. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2007.4300288

Label-free CMOS DNA quantification with on-chip noise reduction schemes

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