Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities

Ninh Khac Ban, Nguyen Thi Kim Thoa, Tran My Linh, Do Thi Trang, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Chau Van Minh, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)290-297
Number of pages8
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - 2018 Jan 1

Bibliographical note

Publisher Copyright:
© 2017, The Japanese Society of Pharmacognosy and Springer Japan KK.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine


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