TY - JOUR
T1 - KNOW-Ped CKD (Korean cohort study for outcomes in patients with pediatric CKD)
T2 - Design and methods
AU - Kang, Hee Gyung
AU - Choi, Hyun Jin
AU - Han, Kyung Hee
AU - Kim, Seong Heon
AU - Cho, Hee Yeon
AU - Cho, Min Hyun
AU - Shin, Jae Il
AU - Lee, Joo Hoon
AU - Lee, Joongyub
AU - Oh, Kook Hwan
AU - Park, Young Seo
AU - Cheong, Hae Il
AU - Ahn, Curie
AU - Ha, Il Soo
N1 - Publisher Copyright:
© 2016 Kang et al.
PY - 2016/3/25
Y1 - 2016/3/25
N2 - Background: The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children's growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government. Methods/design: From seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life. Discussion: With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients. Trial registration: NCT02165878 (ClinicalTrials.gov), submitted on June 11, 2014.
AB - Background: The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children's growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government. Methods/design: From seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life. Discussion: With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients. Trial registration: NCT02165878 (ClinicalTrials.gov), submitted on June 11, 2014.
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U2 - 10.1186/s12882-016-0248-0
DO - 10.1186/s12882-016-0248-0
M3 - Article
C2 - 27012243
AN - SCOPUS:84962245831
SN - 1471-2369
VL - 17
JO - BMC Nephrology
JF - BMC Nephrology
IS - 1
M1 - 35
ER -