Kinetically controlled ligation for the convergent chemical synthesis of proteins

Duhee Bang; Brad L. Pentelute; Stephen B.H. Kent

doi:10.1002/anie.200600702

Kinetically controlled ligation for the convergent chemical synthesis of proteins

Duhee Bang, Brad L. Pentelute, Stephen B.H. Kent

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

225 Citations (Scopus)

Abstract

(Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(^αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.

Original language	English
Pages (from-to)	3985-3988
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	24
DOIs	https://doi.org/10.1002/anie.200600702
Publication status	Published - 2006 Jun 12

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200600702

Cite this

@article{661dc5e5311c455ba1e99d356f838b1c,

title = "Kinetically controlled ligation for the convergent chemical synthesis of proteins",

abstract = "(Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.",

author = "Duhee Bang and Pentelute, {Brad L.} and Kent, {Stephen B.H.}",

year = "2006",

month = jun,

day = "12",

doi = "10.1002/anie.200600702",

language = "English",

volume = "45",

pages = "3985--3988",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "24",

}

TY - JOUR

T1 - Kinetically controlled ligation for the convergent chemical synthesis of proteins

AU - Bang, Duhee

AU - Pentelute, Brad L.

AU - Kent, Stephen B.H.

PY - 2006/6/12

Y1 - 2006/6/12

N2 - (Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.

AB - (Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.

UR - http://www.scopus.com/inward/record.url?scp=33746299267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746299267&partnerID=8YFLogxK

U2 - 10.1002/anie.200600702

DO - 10.1002/anie.200600702

M3 - Article

C2 - 16639756

AN - SCOPUS:33746299267

SN - 1433-7851

VL - 45

SP - 3985

EP - 3988

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24

ER -

Kinetically controlled ligation for the convergent chemical synthesis of proteins

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this