Ixeris dentata decreases ER stress and hepatic lipid accumulation through regulation of ApoB secretion

Mi Rin Lee, Hwa Young Lee, Geum Hwa Lee, Hye Kyung Kim, Nan Young Kim, Seung Hyun Kim, Hyung Ryong Kim, Han Jung Chae

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Nonalcoholic fatty liver disease (NAFLD) is caused by the hepatic accumulation of saturated fatty acids involving the ER stress mechanism. Secretion of apo lipid carrier proteins and their binding to hepatic TG and cholesterol are affected by ER stress. This study was designed to identify ER stress regulators with potential effects against hepatic lipid accumulation. Ixeris dentata (IXD) is a traditional herbal remedy for indigestion, hepatitis, and diabetes used in Korea, Japan, and China. To examine the regulatory effects of IXD against hepatic lipid accumulation and elucidate its suggested mechanism of ER stress, HepG2 hepatocytes were treated with IXD extract in the presence of palmitate. While palmitate induced an ER stress response in hepatocytes, as indicated by the upregulation of PERK, increased eukaryotic initiation factor 2α (eIF2α) phosphorylation, enhanced expression of GADD153/C/EBP homologous protein (CHOP), and reduced secretion of apoB resulting in hepatic cellular accumulation of triglycerides (TG) and cholesterol, IXD extract significantly inhibited the lipid accumulation and PERK/eIF2α/CHOP-axis of the ER stress response. The inhibition of the PERK/eIF2α/CHOP signaling pathway by IXD in palmitate-treated cells suggests that IXD regulates hepatic dyslipidemia through the regulation of ER stress.

Original languageEnglish
Pages (from-to)639-649
Number of pages11
JournalAmerican Journal of Chinese Medicine
Issue number3
Publication statusPublished - 2014

Bibliographical note

Funding Information:
This study was supported by Korea National Research Foundation (2012R1A2A1A03001907 and 2008-0062279).

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine


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