Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung; Hyun Mi Kim; Young Bin Choy; Seong Ju Hwang; Jin Ho Choy

doi:10.1016/j.clay.2007.09.002

Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung, Hyun Mi Kim, Young Bin Choy, Seong Ju Hwang, Jin Ho Choy

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Applied Clay Science
Volume	40
Issue number	1-4
DOIs	https://doi.org/10.1016/j.clay.2007.09.002
Publication status	Published - 2008 Jun

Bibliographical note

Funding Information:
This work was financially supported by the SRC/ERC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (grant: R11-2005-008-00000-0).

All Science Journal Classification (ASJC) codes

Geology
Geochemistry and Petrology

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10.1016/j.clay.2007.09.002

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title = "Itraconazole-Laponite: Kinetics and mechanism of drug release",

abstract = "A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.",

author = "Hyun Jung and Kim, {Hyun Mi} and Choy, {Young Bin} and Hwang, {Seong Ju} and Choy, {Jin Ho}",

note = "Funding Information: This work was financially supported by the SRC/ERC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (grant: R11-2005-008-00000-0). ",

year = "2008",

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doi = "10.1016/j.clay.2007.09.002",

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journal = "Applied Clay Science",

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T2 - Kinetics and mechanism of drug release

AU - Jung, Hyun

AU - Kim, Hyun Mi

AU - Choy, Young Bin

AU - Hwang, Seong Ju

AU - Choy, Jin Ho

N1 - Funding Information: This work was financially supported by the SRC/ERC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (grant: R11-2005-008-00000-0).

PY - 2008/6

Y1 - 2008/6

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AB - A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

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Itraconazole-Laponite: Kinetics and mechanism of drug release

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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