Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung, Hyun Mi Kim, Young Bin Choy, Seong Ju Hwang, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)


A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalApplied Clay Science
Issue number1-4
Publication statusPublished - 2008 Jun

Bibliographical note

Funding Information:
This work was financially supported by the SRC/ERC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (grant: R11-2005-008-00000-0).

All Science Journal Classification (ASJC) codes

  • Geology
  • Geochemistry and Petrology


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