Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study

Meng Li; Xiao Wen Zeng; Zhengmin (Min) Qian; Michael G. Vaughn; Sébastien Sauvé; Gunther Paul; Shao Lin; Long Lu; Li Wen Hu; Bo Yi Yang; Yang Zhou; Xiao Di Qin; Shu Li Xu; Wen Wen Bao; Ya Zhi Zhang; Ping Yuan; Jia Wang; Chuan Zhang; Yan Peng Tian; Min Nian; Xiang Xiao; Chuanxi Fu; Guang Hui Dong

doi:10.1016/j.envint.2017.03.006

Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study

Meng Li, Xiao Wen Zeng, Zhengmin (Min) Qian, Michael G. Vaughn, Sébastien Sauvé, Gunther Paul, Shao Lin, Long Lu, Li Wen Hu, Bo Yi Yang, Yang Zhou, Xiao Di Qin, Shu Li Xu, Wen Wen Bao, Ya Zhi Zhang, Ping Yuan, Jia Wang, Chuan Zhang, Yan Peng Tian, Min NianXiang Xiao, Chuanxi Fu, Guang Hui Dong

Graduate School of Social Welfare

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Environment international
Volume	102
DOIs	https://doi.org/10.1016/j.envint.2017.03.006
Publication status	Published - 2017

Bibliographical note

Funding Information:
This investigation was supported by Grants from the National Natural Science Foundation of China (No. 81472936, No. 81673127 and No. 81172630), the Project for Key Medicine Discipline Construction of Guangzhou Municipality (No. 2017-2019-07), the Fundamental Research Funds for the Central Universities (No. 16ykzd02), and the Natural Science Foundation of Guangdong Province (No. 2016A030313342 and No. 2014A). The views stated within this article are those of the authors and do not necessarily describe the views of the funding source. The funding source did not have control of the design or analysis of the study publication. We thank Dr. Brian B. Boutwell for insightful comments that helped improve the article.

Publisher Copyright:
© 2017

All Science Journal Classification (ASJC) codes

Environmental Science(all)

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10.1016/j.envint.2017.03.006

Cite this

Li, M., Zeng, X. W., Qian, Z., Vaughn, M. G., Sauvé, S., Paul, G., Lin, S., Lu, L., Hu, L. W., Yang, B. Y., Zhou, Y., Qin, X. D., Xu, S. L., Bao, W. W., Zhang, Y. Z., Yuan, P., Wang, J., Zhang, C., Tian, Y. P., ... Dong, G. H. (2017). Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study. Environment international, 102, 1-8. https://doi.org/10.1016/j.envint.2017.03.006

@article{9bf7c6c50b034dcfa9e58f5e966d3d08,

title = "Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study",

abstract = "Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers{\textquoteright} and infants{\textquoteright} characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.",

author = "Meng Li and Zeng, {Xiao Wen} and Qian, {Zhengmin (Min)} and Vaughn, {Michael G.} and S{\'e}bastien Sauv{\'e} and Gunther Paul and Shao Lin and Long Lu and Hu, {Li Wen} and Yang, {Bo Yi} and Yang Zhou and Qin, {Xiao Di} and Xu, {Shu Li} and Bao, {Wen Wen} and Zhang, {Ya Zhi} and Ping Yuan and Jia Wang and Chuan Zhang and Tian, {Yan Peng} and Min Nian and Xiang Xiao and Chuanxi Fu and Dong, {Guang Hui}",

note = "Funding Information: This investigation was supported by Grants from the National Natural Science Foundation of China (No. 81472936, No. 81673127 and No. 81172630), the Project for Key Medicine Discipline Construction of Guangzhou Municipality (No. 2017-2019-07), the Fundamental Research Funds for the Central Universities (No. 16ykzd02), and the Natural Science Foundation of Guangdong Province (No. 2016A030313342 and No. 2014A). The views stated within this article are those of the authors and do not necessarily describe the views of the funding source. The funding source did not have control of the design or analysis of the study publication. We thank Dr. Brian B. Boutwell for insightful comments that helped improve the article. Publisher Copyright: {\textcopyright} 2017",

year = "2017",

doi = "10.1016/j.envint.2017.03.006",

language = "English",

volume = "102",

pages = "1--8",

journal = "Environment international",

issn = "0160-4120",

publisher = "Elsevier Limited",

}

Li, M, Zeng, XW, Qian, Z, Vaughn, MG, Sauvé, S, Paul, G, Lin, S, Lu, L, Hu, LW, Yang, BY, Zhou, Y, Qin, XD, Xu, SL, Bao, WW, Zhang, YZ, Yuan, P, Wang, J, Zhang, C, Tian, YP, Nian, M, Xiao, X, Fu, C & Dong, GH 2017, 'Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study', Environment international, vol. 102, pp. 1-8. https://doi.org/10.1016/j.envint.2017.03.006

TY - JOUR

T1 - Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China

T2 - Guangzhou Birth Cohort Study

AU - Li, Meng

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin (Min)

AU - Vaughn, Michael G.

AU - Sauvé, Sébastien

AU - Paul, Gunther

AU - Lin, Shao

AU - Lu, Long

AU - Hu, Li Wen

AU - Yang, Bo Yi

AU - Zhou, Yang

AU - Qin, Xiao Di

AU - Xu, Shu Li

AU - Bao, Wen Wen

AU - Zhang, Ya Zhi

AU - Yuan, Ping

AU - Wang, Jia

AU - Zhang, Chuan

AU - Tian, Yan Peng

AU - Nian, Min

AU - Xiao, Xiang

AU - Fu, Chuanxi

AU - Dong, Guang Hui

N1 - Funding Information: This investigation was supported by Grants from the National Natural Science Foundation of China (No. 81472936, No. 81673127 and No. 81172630), the Project for Key Medicine Discipline Construction of Guangzhou Municipality (No. 2017-2019-07), the Fundamental Research Funds for the Central Universities (No. 16ykzd02), and the Natural Science Foundation of Guangdong Province (No. 2016A030313342 and No. 2014A). The views stated within this article are those of the authors and do not necessarily describe the views of the funding source. The funding source did not have control of the design or analysis of the study publication. We thank Dr. Brian B. Boutwell for insightful comments that helped improve the article. Publisher Copyright: © 2017

PY - 2017

Y1 - 2017

N2 - Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

AB - Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

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ER -

Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study

Abstract

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