Is human papillomavirus a causative factor of glottic cancer?

Sei Young Lee, Nam Hoon Cho, Eun Chang Choi, Won Shik Kim, Se Heon Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Objectives: Human papillomavirus (HPV) infection is controversial as a causative factor of head and neck cancers despite the relatively high frequency of HPV infection in extragenital organ cancers. We aimed to clarify whether HPV directly affects the oncogenesis and biologic behavior of glottis cancer (GC). Methods: Paraffin block was obtained from 95 patients who were diagnosed as GC and 15 normal controls. HPV genotyping chip, real-time polymerase chain reaction (PCR) was used for identification of prevalence, phenotype, and physical status of HPV. We compared results with the clinicopathological parameters of GC patients. Results: HPV was detected in 7.4% (7 of 95) of GC patients, whereas 0% (0 of 15) of controls. Of the HPV-positive tumors in GCs, HPV-16 was the single most common type and HPV-16 prevalence rate was 57.1% (4 of 7). Among the HPV-16 infected GCs, integration of HPV-16 was found only in one case (1 of 4). There was no significant difference in HPV prevalence between GC and controls and HPV had no significant relation with any clinicopathologic parameters of GC patients. Conclusion: HPV infection may not be a causative factor in the oncogenesis and biologic behavior of GC.

Original languageEnglish
Pages (from-to)770-774
Number of pages5
JournalJournal of Voice
Issue number6
Publication statusPublished - 2011 Nov

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • LPN and LVN
  • Speech and Hearing


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