Is endogenous glycerol a determinant of stratum corneum hydration in humans?

Eung Ho Choi, Mao Qiang Man, Fusheng Wang, Xinjiang Zhang, Barbara E. Brown, Kenneth R. Feingold, Peter M. Elias

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)


Although stratum corneum (SC) hydration has been primarily of concern to the cosmetic industry, it serves an important biosensor function. In murine models, not only deiminated products of filaggrin-derived amino acids ("NMF") but also endogenous glycerol from circulation into the epidermis via aquaporin 3 channel and from triglyceride turnover in sebaceous glands (SG) are important determinants. We assessed here whether endogenous glycerol could also be linked to SC hydration in humans. SG-enriched sites are more hydrated than SG-impoverished sites, and SC hydration correlates with both sebum production and SC glycerol content, but the correlation is more significant for SC glycerol content than for sebum content. Moreover, gender-related differences in sebum content are not associated with altered SC hydration. SC hydration is also linked to SC glycerol content in SG-impoverished sites, suggesting a role for non-SG-derived (? from circulation) glycerol in SC hydration. Finally, short-term water immersion produces a parallel decline in SC hydration and SC glycerol content, with glycerol levels returning to normal over several hours. These results suggest that endogenous glycerol of both circulatory and SG origin comprises an H2O-extractable pool that influences SC hydration in humans. These results also provide a rationale for the development of glycerol-containing therapeutic moisturizers.

Original languageEnglish
Pages (from-to)288-293
Number of pages6
JournalJournal of Investigative Dermatology
Issue number2
Publication statusPublished - 2005 Aug

Bibliographical note

Funding Information:
Jerelyn Magnusson provided valuable secretarial assistance. This work was supported by NIH grants AR 19098, AR 39448 (PP), the Medical Research Service, Department of Veterans Affairs, and by a grant from Estee Lauder.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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