Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor

Soo A. Kim, Sang Gun Ahn, Su Gwan Kim, Joo Cheol Park, Sang Ho Lee, Jin Kim, Jung Hoon Yoon

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34 Citations (Scopus)


Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Issue number1
Publication statusPublished - 2007 Jan

Bibliographical note

Funding Information:
This study was supported by research funds from Chosun University, Korea (2003).

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • General Dentistry


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