Investigation of Keratinizing Squamous Cell Carcinoma of the Tongue Using Terahertz Reflection Imaging

Young Bin Ji; Jung Min Kim; Young Han Lee; Yuna Choi; Da Hee Kim; Yong Min Huh; Seung Jae Oh; Yoon Woo Koh; Jin Suck Suh

doi:10.1007/s10762-018-0562-7

Investigation of Keratinizing Squamous Cell Carcinoma of the Tongue Using Terahertz Reflection Imaging

Young Bin Ji, Jung Min Kim, Young Han Lee, Yuna Choi, Da Hee Kim, Yong Min Huh, Seung Jae Oh, Yoon Woo Koh, Jin Suck Suh

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9 Citations (Scopus)

Abstract

We investigated the feasibility of using terahertz (THz) reflection imaging to detect keratinizing squamous cell carcinoma (SCC) of the tongue. Four fresh keratinizing SCC tissues were studied, which had been surgically resected. All of the keratinizing SCCs were well distinguished from normal healthy tissues. We showed that the tumor regions exhibited low THz reflection despite having higher water content than normal regions. The refractive indices and absorption coefficients were low in the tumor tissues despite the relatively high water content. Our results showed that there were dominant factors such as keratin pearls, other than the water content affecting the THz reflection signal.

Original language	English
Pages (from-to)	247-256
Number of pages	10
Journal	Journal of Infrared, Millimeter, and Terahertz Waves
Volume	40
Issue number	2
DOIs	https://doi.org/10.1007/s10762-018-0562-7
Publication status	Published - 2019 Feb 1

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MOE) (2016R1D1A1B03933168, NRF-2017R1A2B1010381); Korea Health Industry Development Institute (KHIDI) grant funded by the Ministry of Health & Welfare, Republic of Korea (HI16C0179); Technology Innovation Program funded By the Ministry of Trade, industry & Energy (MI, Korea) (10060136); KIST intramural funding grant (2E27270).

Funding Information:
Acknowledgments This work was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MOE) (2016R1D1A1B03933168, NRF-2017R1A2B1010381); Korea Health Industry Development Institute (KHIDI) grant funded by the Ministry of Health & Welfare, Republic of Korea (HI16C0179); Technology Innovation Program funded By the Ministry of Trade, industry & Energy (MI, Korea) (10060136); KIST intramural funding grant (2E27270).

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

All Science Journal Classification (ASJC) codes

Radiation
Instrumentation
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1007/s10762-018-0562-7

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title = "Investigation of Keratinizing Squamous Cell Carcinoma of the Tongue Using Terahertz Reflection Imaging",

abstract = "We investigated the feasibility of using terahertz (THz) reflection imaging to detect keratinizing squamous cell carcinoma (SCC) of the tongue. Four fresh keratinizing SCC tissues were studied, which had been surgically resected. All of the keratinizing SCCs were well distinguished from normal healthy tissues. We showed that the tumor regions exhibited low THz reflection despite having higher water content than normal regions. The refractive indices and absorption coefficients were low in the tumor tissues despite the relatively high water content. Our results showed that there were dominant factors such as keratin pearls, other than the water content affecting the THz reflection signal.",

author = "Ji, {Young Bin} and Kim, {Jung Min} and Lee, {Young Han} and Yuna Choi and Kim, {Da Hee} and Huh, {Yong Min} and Oh, {Seung Jae} and Koh, {Yoon Woo} and Suh, {Jin Suck}",

note = "Funding Information: This work was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MOE) (2016R1D1A1B03933168, NRF-2017R1A2B1010381); Korea Health Industry Development Institute (KHIDI) grant funded by the Ministry of Health & Welfare, Republic of Korea (HI16C0179); Technology Innovation Program funded By the Ministry of Trade, industry & Energy (MI, Korea) (10060136); KIST intramural funding grant (2E27270). Funding Information: Acknowledgments This work was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MOE) (2016R1D1A1B03933168, NRF-2017R1A2B1010381); Korea Health Industry Development Institute (KHIDI) grant funded by the Ministry of Health & Welfare, Republic of Korea (HI16C0179); Technology Innovation Program funded By the Ministry of Trade, industry & Energy (MI, Korea) (10060136); KIST intramural funding grant (2E27270). Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Huh, Yong Min

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AU - Koh, Yoon Woo

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PY - 2019/2/1

Y1 - 2019/2/1

N2 - We investigated the feasibility of using terahertz (THz) reflection imaging to detect keratinizing squamous cell carcinoma (SCC) of the tongue. Four fresh keratinizing SCC tissues were studied, which had been surgically resected. All of the keratinizing SCCs were well distinguished from normal healthy tissues. We showed that the tumor regions exhibited low THz reflection despite having higher water content than normal regions. The refractive indices and absorption coefficients were low in the tumor tissues despite the relatively high water content. Our results showed that there were dominant factors such as keratin pearls, other than the water content affecting the THz reflection signal.

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Investigation of Keratinizing Squamous Cell Carcinoma of the Tongue Using Terahertz Reflection Imaging

Abstract

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