Introduction to single-cell dna methylation profiling methods

Jongseong Ahn, Sunghoon Heo, Jihyun Lee, Duhee Bang

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.

Original languageEnglish
Article number1013
JournalBiomolecules
Volume11
Issue number7
DOIs
Publication statusPublished - 2021 Jul

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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