We evaluated the efficacy of β-radiation therapy (188Re-MAG3) to inhibit intimal hyperplasia (IH) in diffuse in-stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients. Nine patients who did not agree with radiation therapy, and therefore underwent rotational atherectomy and balloon angioplasty for diffuse in-stent restenosis in the same study period, were selected for control groups. Serial IVUS comparisons were available in 44 of 50 patients with radiation therapy and 7 of 9 control patients. At 6-month follow-up, there was less significant increase of IH area in patients with radiation therapy than in control patients (Δ IH area = 0.1±0.8 mm2 vs. 2.6±1.8 mm2, P>0.001 in mean values, and 0.6±1.4 mm2 vs. 2.9±2.1 mm2, P = 0.026 in values of follow-up lesion site, respectively). In conclusion, β-radiation therapy might be an effective treatment modality to inhibit intimal hyperplasia in patients with diffuse in-stent restenosis.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine