Intraocular Pressure Monitoring following Islet Transplantation to the Anterior Chamber of the Eye

Joohee Kim; Jaeyoon Kim; Minjae Ku; Eunkyung Cha; Seoyoung Ju; Won Yeong Park; Ki Hean Kim; Dai Woo Kim; Per Olof Berggren; Jang Ung Park

doi:10.1021/acs.nanolett.9b03605

Intraocular Pressure Monitoring following Islet Transplantation to the Anterior Chamber of the Eye

Joohee Kim, Jaeyoon Kim, Minjae Ku, Eunkyung Cha, Seoyoung Ju, Won Yeong Park, Ki Hean Kim, Dai Woo Kim, Per Olof Berggren, Jang Ung Park

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Intraocular islet transplantation was investigated as a new procedure to treat diabetes. The development of this procedure requires close monitoring of the function of both eye and islet graft. We developed a soft, smart contact lens to monitor the intraocular pressure and applied this for noninvasive monitoring in association with the intraocular islet transplantation in diabetes. A strain sensor inside the lens can detect detailed changes in intraocular pressure by focusing the strain only in the desired, selective area of the contact lens. In addition, this smart contact lens can transmit the real-time value of the intraocular pressure wirelessly using an antenna. The wireless measurement of intraocular pressure that was obtained using this contact lens had a high correlation with the intraocular pressure measured by a rebound tonometer, thereby proving the good accuracy of the contact lens sensor. In the initial period, a slight elevation of intraocular pressure was observed, but the pressure returned to normal in the initial period after the transplantation. This type of monitoring will provide important information on potential changes in the intraocular pressure associated with the transplantation procedure, and it enables appropriate clinical safety steps to be taken, if needed.

Original language	English
Pages (from-to)	1517-1525
Number of pages	9
Journal	Nano letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1021/acs.nanolett.9b03605
Publication status	Published - 2020 Mar 11

Bibliographical note

Funding Information:
This work was supported by the Ministry of Science & ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358, 2016R1A5A1009926, and 2018R1A6A3A11046983), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2015M3A7B4050308 and 2016M3A7B4910635), and the Industrial Technology Innovation Program (10080577). It was also supported by the Swedish Research Council, the Novo Nordisk Foundation, Karolinska Institutet, the Swedish Diabetes Association, The Family Knut and Alice Wallenberg Foundation, Diabetes Research and Wellness Foundation, Swedish Foundation for Strategic Research, Berth von Kantzow’s Foundation, The Skandia Insurance Company Ltd., Strategic Research Programme in Diabetes at Karolinska Institutet, ERC-2013-AdG 338936-BetaImage, the Stichting af Jochnick Foundation, and the Family Erling-Persson Foundation. Also, the authors acknowledge financial support by the Institute for Basic Science (IBS-R026-D1), the Research Program (2018-22-0194), and Post Doc Researcher Supporting program of 2019 (2019-12-0010) funded by Yonsei University.

Publisher Copyright:
© 2019 American Chemical Society.

All Science Journal Classification (ASJC) codes

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/acs.nanolett.9b03605

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@article{0cea69dcc4a8401586864357a0de8b37,

title = "Intraocular Pressure Monitoring following Islet Transplantation to the Anterior Chamber of the Eye",

abstract = "Intraocular islet transplantation was investigated as a new procedure to treat diabetes. The development of this procedure requires close monitoring of the function of both eye and islet graft. We developed a soft, smart contact lens to monitor the intraocular pressure and applied this for noninvasive monitoring in association with the intraocular islet transplantation in diabetes. A strain sensor inside the lens can detect detailed changes in intraocular pressure by focusing the strain only in the desired, selective area of the contact lens. In addition, this smart contact lens can transmit the real-time value of the intraocular pressure wirelessly using an antenna. The wireless measurement of intraocular pressure that was obtained using this contact lens had a high correlation with the intraocular pressure measured by a rebound tonometer, thereby proving the good accuracy of the contact lens sensor. In the initial period, a slight elevation of intraocular pressure was observed, but the pressure returned to normal in the initial period after the transplantation. This type of monitoring will provide important information on potential changes in the intraocular pressure associated with the transplantation procedure, and it enables appropriate clinical safety steps to be taken, if needed.",

author = "Joohee Kim and Jaeyoon Kim and Minjae Ku and Eunkyung Cha and Seoyoung Ju and Park, {Won Yeong} and Kim, {Ki Hean} and Kim, {Dai Woo} and Berggren, {Per Olof} and Park, {Jang Ung}",

note = "Funding Information: This work was supported by the Ministry of Science & ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358, 2016R1A5A1009926, and 2018R1A6A3A11046983), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2015M3A7B4050308 and 2016M3A7B4910635), and the Industrial Technology Innovation Program (10080577). It was also supported by the Swedish Research Council, the Novo Nordisk Foundation, Karolinska Institutet, the Swedish Diabetes Association, The Family Knut and Alice Wallenberg Foundation, Diabetes Research and Wellness Foundation, Swedish Foundation for Strategic Research, Berth von Kantzow{\textquoteright}s Foundation, The Skandia Insurance Company Ltd., Strategic Research Programme in Diabetes at Karolinska Institutet, ERC-2013-AdG 338936-BetaImage, the Stichting af Jochnick Foundation, and the Family Erling-Persson Foundation. Also, the authors acknowledge financial support by the Institute for Basic Science (IBS-R026-D1), the Research Program (2018-22-0194), and Post Doc Researcher Supporting program of 2019 (2019-12-0010) funded by Yonsei University. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2020",

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doi = "10.1021/acs.nanolett.9b03605",

language = "English",

volume = "20",

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T1 - Intraocular Pressure Monitoring following Islet Transplantation to the Anterior Chamber of the Eye

AU - Kim, Joohee

AU - Kim, Jaeyoon

AU - Ku, Minjae

AU - Cha, Eunkyung

AU - Ju, Seoyoung

AU - Park, Won Yeong

AU - Kim, Ki Hean

AU - Kim, Dai Woo

AU - Berggren, Per Olof

AU - Park, Jang Ung

N1 - Funding Information: This work was supported by the Ministry of Science & ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358, 2016R1A5A1009926, and 2018R1A6A3A11046983), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2015M3A7B4050308 and 2016M3A7B4910635), and the Industrial Technology Innovation Program (10080577). It was also supported by the Swedish Research Council, the Novo Nordisk Foundation, Karolinska Institutet, the Swedish Diabetes Association, The Family Knut and Alice Wallenberg Foundation, Diabetes Research and Wellness Foundation, Swedish Foundation for Strategic Research, Berth von Kantzow’s Foundation, The Skandia Insurance Company Ltd., Strategic Research Programme in Diabetes at Karolinska Institutet, ERC-2013-AdG 338936-BetaImage, the Stichting af Jochnick Foundation, and the Family Erling-Persson Foundation. Also, the authors acknowledge financial support by the Institute for Basic Science (IBS-R026-D1), the Research Program (2018-22-0194), and Post Doc Researcher Supporting program of 2019 (2019-12-0010) funded by Yonsei University. Publisher Copyright: © 2019 American Chemical Society.

PY - 2020/3/11

Y1 - 2020/3/11

N2 - Intraocular islet transplantation was investigated as a new procedure to treat diabetes. The development of this procedure requires close monitoring of the function of both eye and islet graft. We developed a soft, smart contact lens to monitor the intraocular pressure and applied this for noninvasive monitoring in association with the intraocular islet transplantation in diabetes. A strain sensor inside the lens can detect detailed changes in intraocular pressure by focusing the strain only in the desired, selective area of the contact lens. In addition, this smart contact lens can transmit the real-time value of the intraocular pressure wirelessly using an antenna. The wireless measurement of intraocular pressure that was obtained using this contact lens had a high correlation with the intraocular pressure measured by a rebound tonometer, thereby proving the good accuracy of the contact lens sensor. In the initial period, a slight elevation of intraocular pressure was observed, but the pressure returned to normal in the initial period after the transplantation. This type of monitoring will provide important information on potential changes in the intraocular pressure associated with the transplantation procedure, and it enables appropriate clinical safety steps to be taken, if needed.

AB - Intraocular islet transplantation was investigated as a new procedure to treat diabetes. The development of this procedure requires close monitoring of the function of both eye and islet graft. We developed a soft, smart contact lens to monitor the intraocular pressure and applied this for noninvasive monitoring in association with the intraocular islet transplantation in diabetes. A strain sensor inside the lens can detect detailed changes in intraocular pressure by focusing the strain only in the desired, selective area of the contact lens. In addition, this smart contact lens can transmit the real-time value of the intraocular pressure wirelessly using an antenna. The wireless measurement of intraocular pressure that was obtained using this contact lens had a high correlation with the intraocular pressure measured by a rebound tonometer, thereby proving the good accuracy of the contact lens sensor. In the initial period, a slight elevation of intraocular pressure was observed, but the pressure returned to normal in the initial period after the transplantation. This type of monitoring will provide important information on potential changes in the intraocular pressure associated with the transplantation procedure, and it enables appropriate clinical safety steps to be taken, if needed.

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Intraocular Pressure Monitoring following Islet Transplantation to the Anterior Chamber of the Eye

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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