Intraocular Pressure Monitoring following Islet Transplantation to the Anterior Chamber of the Eye

Joohee Kim, Jaeyoon Kim, Minjae Ku, Eunkyung Cha, Seoyoung Ju, Won Yeong Park, Ki Hean Kim, Dai Woo Kim, Per Olof Berggren, Jang Ung Park

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34 Citations (Scopus)


Intraocular islet transplantation was investigated as a new procedure to treat diabetes. The development of this procedure requires close monitoring of the function of both eye and islet graft. We developed a soft, smart contact lens to monitor the intraocular pressure and applied this for noninvasive monitoring in association with the intraocular islet transplantation in diabetes. A strain sensor inside the lens can detect detailed changes in intraocular pressure by focusing the strain only in the desired, selective area of the contact lens. In addition, this smart contact lens can transmit the real-time value of the intraocular pressure wirelessly using an antenna. The wireless measurement of intraocular pressure that was obtained using this contact lens had a high correlation with the intraocular pressure measured by a rebound tonometer, thereby proving the good accuracy of the contact lens sensor. In the initial period, a slight elevation of intraocular pressure was observed, but the pressure returned to normal in the initial period after the transplantation. This type of monitoring will provide important information on potential changes in the intraocular pressure associated with the transplantation procedure, and it enables appropriate clinical safety steps to be taken, if needed.

Original languageEnglish
Pages (from-to)1517-1525
Number of pages9
JournalNano letters
Issue number3
Publication statusPublished - 2020 Mar 11

Bibliographical note

Funding Information:
This work was supported by the Ministry of Science & ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358, 2016R1A5A1009926, and 2018R1A6A3A11046983), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2015M3A7B4050308 and 2016M3A7B4910635), and the Industrial Technology Innovation Program (10080577). It was also supported by the Swedish Research Council, the Novo Nordisk Foundation, Karolinska Institutet, the Swedish Diabetes Association, The Family Knut and Alice Wallenberg Foundation, Diabetes Research and Wellness Foundation, Swedish Foundation for Strategic Research, Berth von Kantzow’s Foundation, The Skandia Insurance Company Ltd., Strategic Research Programme in Diabetes at Karolinska Institutet, ERC-2013-AdG 338936-BetaImage, the Stichting af Jochnick Foundation, and the Family Erling-Persson Foundation. Also, the authors acknowledge financial support by the Institute for Basic Science (IBS-R026-D1), the Research Program (2018-22-0194), and Post Doc Researcher Supporting program of 2019 (2019-12-0010) funded by Yonsei University.

Publisher Copyright:
© 2019 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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