Intracranial squamous cell carcinoma arising in a cerebellopontine angle epidermoid cyst: A case report and literature review

Tae Hoon Roh, Yong Sook Park, Yong Gou Park, Se Hoon Kim, Jong Hee Chang

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Rationale: Most of the intracranial epidermoid cysts are benign, but malignant lesions are occasionally reported. These lesions appear as squamous cell carcinoma and carry a dismal prognosis. Here, we report a case of a primary intracranial squamous cell carcinoma arising in a cerebellopontine epidermoid cyst. The relevant literatures were also reviewed. Patient concerns: A 53-year-old woman presented with dizziness and diplopia 9 months in duration. Magnetic resonance imaging revealed an epidermoid cyst in the left cerebellopontine angle and prepontine region with a focal enhancing lesion on T1-weighted gadolinium-enhanced images. Diagnoses: Histopathologic diagnosis revealed squamous cell carcinoma on a background of epidermoid cyst. Imaging studies excluded metastases. Interventions: The tumor was removed subtotally through a lateral suboccipital approach. The patient received intensity modulated radiation therapy (6720cGy total) postoperatively. Outcomes: The patient was free from recurrence of the tumor until 3 years after surgery, at which point she was lost to follow-up. The patient died 4 years after the surgery. Lessons: The epidermoid cyst may occasionally become malignant. Finding an area of enhancement through preoperative magnetic resonance imaging can help to make a correct diagnosis. Based on the review of previous reports, surgical removal followed by radiotherapy shows the best result to treat malignant epidermoid cysts.

Original languageEnglish
Article numbere9423
JournalMedicine (United States)
Issue number51
Publication statusPublished - 2017 Dec 1

Bibliographical note

Publisher Copyright:
© 2017 the Author(s).

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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