Intracellular infection of Cutibacterium acnes in macrophages of extensive peri-implantitis lesions: A clinical case series

Jin Young Park, Dawool Han, Yuan Park, Eunae Sandra Cho, Jong In Yook, Jung Seok Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Cutibacterium acnes is a facultative anaerobic, gram-positive rod, and a commensal bacterium of the body surface including oral cavity. A causal relationship between C. acnes and chronic granulomatous diseases, such as sarcoidosis and orthopedic implant-associated infections, has been previously reported. Typically, C. acnes has been observed inside macrophages, allowing evasion of host immunity, and triggering a persistent inflammatory response. However, such findings have not been reported in peri-implantitis lesions. In this case series, we collected inflamed tissues from extensive peri-implantitis lesions of eight patients. Out of the eight samples, seven tested positive for the 16 s rRNA gene of C. acnes by polymerase chain reaction, and six were positive by immunohistochemistry. Immunohistochemical staining revealed the presence of C. acnes in the cytoplasm of macrophages, suggesting a role in lesion formation. This finding may enhance our understanding of the pathophysiology of persistent peri-implantitis lesions and provide implications for future therapy.

Original languageEnglish
Pages (from-to)1126-1134
Number of pages9
JournalClinical Implant Dentistry and Related Research
Volume26
Issue number6
DOIs
Publication statusPublished - 2024 Dec

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Clinical Implant Dentistry and Related Research published by Wiley Periodicals LLC.

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • General Dentistry

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