TY - JOUR
T1 - Intracellular infection of Cutibacterium acnes in macrophages of extensive peri-implantitis lesions
T2 - A clinical case series
AU - Park, Jin Young
AU - Han, Dawool
AU - Park, Yuan
AU - Cho, Eunae Sandra
AU - In Yook, Jong
AU - Lee, Jung Seok
N1 - Publisher Copyright:
© 2024 The Author(s). Clinical Implant Dentistry and Related Research published by Wiley Periodicals LLC.
PY - 2024/12
Y1 - 2024/12
N2 - Cutibacterium acnes is a facultative anaerobic, gram-positive rod, and a commensal bacterium of the body surface including oral cavity. A causal relationship between C. acnes and chronic granulomatous diseases, such as sarcoidosis and orthopedic implant-associated infections, has been previously reported. Typically, C. acnes has been observed inside macrophages, allowing evasion of host immunity, and triggering a persistent inflammatory response. However, such findings have not been reported in peri-implantitis lesions. In this case series, we collected inflamed tissues from extensive peri-implantitis lesions of eight patients. Out of the eight samples, seven tested positive for the 16 s rRNA gene of C. acnes by polymerase chain reaction, and six were positive by immunohistochemistry. Immunohistochemical staining revealed the presence of C. acnes in the cytoplasm of macrophages, suggesting a role in lesion formation. This finding may enhance our understanding of the pathophysiology of persistent peri-implantitis lesions and provide implications for future therapy.
AB - Cutibacterium acnes is a facultative anaerobic, gram-positive rod, and a commensal bacterium of the body surface including oral cavity. A causal relationship between C. acnes and chronic granulomatous diseases, such as sarcoidosis and orthopedic implant-associated infections, has been previously reported. Typically, C. acnes has been observed inside macrophages, allowing evasion of host immunity, and triggering a persistent inflammatory response. However, such findings have not been reported in peri-implantitis lesions. In this case series, we collected inflamed tissues from extensive peri-implantitis lesions of eight patients. Out of the eight samples, seven tested positive for the 16 s rRNA gene of C. acnes by polymerase chain reaction, and six were positive by immunohistochemistry. Immunohistochemical staining revealed the presence of C. acnes in the cytoplasm of macrophages, suggesting a role in lesion formation. This finding may enhance our understanding of the pathophysiology of persistent peri-implantitis lesions and provide implications for future therapy.
KW - Cutibacterium acnes
KW - case report
KW - immunohistochemistry
KW - peri-implantitis
KW - polymerase chain reaction
UR - http://www.scopus.com/inward/record.url?scp=85201075828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85201075828&partnerID=8YFLogxK
U2 - 10.1111/cid.13367
DO - 10.1111/cid.13367
M3 - Article
AN - SCOPUS:85201075828
SN - 1523-0899
VL - 26
SP - 1126
EP - 1134
JO - Clinical Implant Dentistry and Related Research
JF - Clinical Implant Dentistry and Related Research
IS - 6
ER -