Intra-arterial thrombolytic therapy for hyperacute ischemic stroke caused by tandem occlusion

Dong Joon Kim, Dong Ik Kim, Joon Soo Byun, Jin Young Jung, Sang Hyun Suh, Eung Yeop Kim, Ji Hoe Heo

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Background: Tandem occlusion of the arteries at the extracranial and intracranial segments is a unique cause of ischemic stroke and is often associated with a poor prognosis. Although tandem occlusion is occasionally found during intra-arterial thrombolysis (IAT), as of yet no clear therapeutic strategy has been elucidated. Methods: After identifying distal intradural (DIL) and proximal extradural lesions (PEL) as well as the collateral state and clot burden, IAT was performed primarily targeting DIL by navigation of the microcatheter through the PEL or a collateral pathway. Results: Among 147 consecutive patients who were treated with IAT for hyperacute ischemic stroke, 13 (11.4%) were identified to have tandem occlusion as the cause of stroke. Navigation of a microcatheter through occluded PEL (internal carotid artery/vertebral artery) or a collateral pathway (anterior communicating artery) to the DIL was successful in 9 patients. Of them, recanalization of the DIL could be achieved in 8 (89%). The overall recanalization rate among all patients with tandem occlusion was (62%, 8/13). A good functional outcome (modified Rankin score ≤2) at 3 months was noted in 6 patients (46.2%). Conclusions: Tandem occlusion may be successfully managed by strategic thrombolysis of the DIL as the primary therapeutic target for IAT. By this strategy, the ischemic brain could be effectively and rapidly perfused.

Original languageEnglish
Pages (from-to)184-189
Number of pages6
JournalCerebrovascular Diseases
Issue number2
Publication statusPublished - 2008 Aug

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Intra-arterial thrombolytic therapy for hyperacute ischemic stroke caused by tandem occlusion'. Together they form a unique fingerprint.

Cite this