Intestinal bacteria and development of the B-lymphocyte repertoire

Dennis K. Lanning, Ki Jong Rhee, Katherine L. Knight

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)


Vertebrates have a large antibody repertoire with diverse antigen specificities, poised to react to invading pathogens, such as bacteria, viruses and helminths. In some species, microbes such as these are required for development of both diverse antibody and B-lymphocyte repertoires. Recent studies demonstrate that B-lymphocyte expansion, selection and somatic diversification of Ig genes are regulated in these species, in part, by the interaction between commensal intestinal bacteria and gut-associated lymphoid tissue (GALT). These findings indicate that the commensal microbiota can shape the repertoire of peripheral B lymphocytes and can potentially influence the health of the host. Here, how the interactions between commensal microbiota and lymphoid cells of GALT might affect the development of the peripheral B-lymphocyte repertoire is discussed.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalTrends in Immunology
Issue number8
Publication statusPublished - 2005 Aug

Bibliographical note

Funding Information:
This work was supported by PHS grants AI50260 (KLK) and AI49458 (DKL).

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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