Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression

Se Jung Lee; Seok Cheol Cho; Eo Jin Lee; Sangtae Kim; Soo Bok Lee; Jung Hyurk Lim; Yung Hyun Choi; Wun Jae Kim; Sung Kwon Moon

doi:10.1074/jbc.M112.410233

Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression

Se Jung Lee, Seok Cheol Cho, Eo Jin Lee, Sangtae Kim, Soo Bok Lee, Jung Hyurk Lim, Yung Hyun Choi, Wun Jae Kim, Sung Kwon Moon

Department of Food and Nutrition

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

Original language	English
Pages (from-to)	5539-5552
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.410233
Publication status	Published - 2013 Feb 22

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Lee, S. J., Cho, S. C., Lee, E. J., Kim, S., Lee, S. B., Lim, J. H., Choi, Y. H., Kim, W. J., & Moon, S. K. (2013). Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression. Journal of Biological Chemistry, 288(8), 5539-5552. https://doi.org/10.1074/jbc.M112.410233

Lee, Se Jung ; Cho, Seok Cheol ; Lee, Eo Jin et al. / Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 8. pp. 5539-5552.

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title = "Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression",

abstract = "Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.",

author = "Lee, {Se Jung} and Cho, {Seok Cheol} and Lee, {Eo Jin} and Sangtae Kim and Lee, {Soo Bok} and Lim, {Jung Hyurk} and Choi, {Yung Hyun} and Kim, {Wun Jae} and Moon, {Sung Kwon}",

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day = "22",

doi = "10.1074/jbc.M112.410233",

language = "English",

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pages = "5539--5552",

journal = "Journal of Biological Chemistry",

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Lee, SJ, Cho, SC, Lee, EJ, Kim, S, Lee, SB, Lim, JH, Choi, YH, Kim, WJ & Moon, SK 2013, 'Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression', Journal of Biological Chemistry, vol. 288, no. 8, pp. 5539-5552. https://doi.org/10.1074/jbc.M112.410233

Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression. / Lee, Se Jung; Cho, Seok Cheol; Lee, Eo Jin et al.
In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5539-5552.

Research output: Contribution to journal › Article › peer-review

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T1 - Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression

AU - Lee, Se Jung

AU - Cho, Seok Cheol

AU - Lee, Eo Jin

AU - Kim, Sangtae

AU - Lee, Soo Bok

AU - Lim, Jung Hyurk

AU - Choi, Yung Hyun

AU - Kim, Wun Jae

AU - Moon, Sung Kwon

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

AB - Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

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Lee SJ, Cho SC, Lee EJ, Kim S, Lee SB, Lim JH et al. Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression. Journal of Biological Chemistry. 2013 Feb 22;288(8):5539-5552. doi: 10.1074/jbc.M112.410233

Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression

Abstract

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