Interindividual reproducibility of glutamate quantification using 1.5-T proton magnetic resonance spectroscopy

Dong Pyo Jang, Jong Min Lee, Eun Lee, Sangjin Park, Jae Jin Kim, Kee Namkoong, Kang Jun Yoon, In Young Kim, Sun I. Kim

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T 1H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest - 4 cm3). The average Cramér-Rao lower bounds for glutamate quantification using LCModel was lowest in two experiments when TE = 40 ms. Twenty-one subjects participated in experiments that measured interindividual reproducibility of glutamate quantification. Spectra were acquired with TR = 6000 ms and TE = 40 ms. Results showed that the coefficients of variance were 11.0 and 13.1% in the anterior cingulate cortex and insula, respectively. This suggests that glutamate can be reproducibly measured from 1.5-T 1H MRS with long TR, effective TE, and the LCModel.

Original languageEnglish
Pages (from-to)708-712
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number3
Publication statusPublished - 2005 Mar

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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