Interferon alpha-2a treatment for refractory Behcet uveitis in Korean patients

Ji Hwan Lee, Christopher Seungkyu Lee, Sung Chul Lee

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: To evaluate therapeutic outcomes of interferon alpha-2a (IFNα2a) treatment in patients with Behcet's disease who were refractory to immunosuppressive agents. Methods: This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. IFNα2a was administered at a dose of 3 million IU 3 times per week. Clinical response, relapse rate, and change of visual acuity were evaluated. Results: The mean age of patients was 39.60 ± 9.21 years, and the median treatment duration was 6 months. Four of the 5 patients (80%) presented with responses to IFNα2a without any uveitis attack during the treatment period. The mean number of uveitis attacks/year per patient during the treatment was 0.40 ± 0.89. The mean log of the Minimum Angle of Resolution visual acuity improved from 1.44 ± 0.38 at baseline to 1.02 ± 0.58 at the final follow up. Conclusions: IFNα2a is an effective therapy for Behcet uveitis refractory to conventional immunosuppressants in Korean patients.

Original languageEnglish
Article number52
JournalBMC Ophthalmology
Issue number1
Publication statusPublished - 2018 Feb 20

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

All Science Journal Classification (ASJC) codes

  • Ophthalmology


Dive into the research topics of 'Interferon alpha-2a treatment for refractory Behcet uveitis in Korean patients'. Together they form a unique fingerprint.

Cite this