Intereye Comparison of the Characteristics of the Peripapillary Choroid in Patients with Unilateral Normal-Tension Glaucoma

Jeong Ah Kim, Dong Hwan Son, Eun Ji Lee, Hyunjoong Kim, Tae Woo Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Purpose: To compare the characteristics of the peripapillary choroid (PPC) between the 2 eyes of patients with unilateral treatment-naïve normal-tension glaucoma (NTG). Design: Observational case series. Participants: Sixty-nine patients (138 eyes) with treatment-naïve unilateral NTG. Methods: The characteristics of PPC vasculature were evaluated by measuring PPC thickness and assessing the presence of parapapillary deep-layer microvasculature dropout (MvD). Peripapillary choroid thickness was measured by enhanced depth imaging OCT. Microvasculature dropout was assessed using OCT angiography. The area and maximum radial width of β-zone parapapillary atrophy (PPA) were measured on infrared images using the built-in caliper tool of the Spectralis OCT (Heidelberg Engineering). Main Outcome Measures: Between-eye differences in PPC thickness, MvD frequency, and the area and maximum width of β-zone PPA. Results: Eyes with NTG showed higher intraocular pressure (IOP), longer axial length, thinner PPC, larger area and maximum radial width of the β-zone PPA, and more frequent MvD (P < 0.01 for each) than contralateral healthy eyes. Multivariate conditional logistic regression analysis revealed that higher IOP, thinner PPC, larger maximum radial width of β-zone PPA, and the presence of MvD were associated independently with the risk of NTG (P < 0.03 for each). In eyes with NTG, MvD location and retinal nerve fiber layer defect were correlated topographically. Conclusions: Peripapillary choroid vasculature characteristics are significantly more compromised in eyes with NTG than in contralateral healthy eyes of patients with unilateral NTG.

Original languageEnglish
Pages (from-to)512-521
Number of pages10
JournalOphthalmology Glaucoma
Volume4
Issue number5
DOIs
Publication statusPublished - 2021 Sept 1

Bibliographical note

Publisher Copyright:
© 2021 American Academy of Ophthalmology

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Fingerprint

Dive into the research topics of 'Intereye Comparison of the Characteristics of the Peripapillary Choroid in Patients with Unilateral Normal-Tension Glaucoma'. Together they form a unique fingerprint.

Cite this