Integrative approach to elderly frailty

Byoung Jin Park, Yong Jae Lee

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


Elderly frailty has been recognized as a distinct clinical syndrome with a physiologic basis. It reflects a decreased functional reserve and consequent reduction in resilience to any stressors. It is important to understand that frailty process could be a transitional state with dynamic properties: normal aging→pre-frail→frailty→complication status. Hence, frailty could be preventable and its progression may be delayed. Furthermore, there is the potential reversibility of many of its features. The earlier stages of frailty might not be clinically apparent, but later stages manifest as significant deficits accumulate. The major phenotype of frailty includes weight loss, sarcopenia, relative inactivity, decreased balance and mobility, decreased cognitive function, and impaired nutritional status. Therefore, frail patients could be implicated by decreased performance status and have a significantly increased risk of cardiovascular diseases, cancer, falls and mortality. Regular exercise, essential amino acid and vitamin D are recommendable to prevent and treat elderly frailty, but hormone replacement therapy does not have consistent evidence yet. In upcoming (super) aging society, the importance of elderly frailty would be more noticed and multidisplinary approach should be actively performed.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalKorean Journal of Family Medicine
Issue number10
Publication statusPublished - 2010 Oct

All Science Journal Classification (ASJC) codes

  • Family Practice


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