Insulin-like growth factor II mRNA-binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma

Shengjin Li; Jeongdan Cha; Jin Kim; Ki Yeol Kim; Hyung Jun Kim; Woong Nam; In Ho Cha

doi:10.1002/hed.21457

Insulin-like growth factor II mRNA-binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma

Shengjin Li, Jeongdan Cha, Jin Kim, Ki Yeol Kim, Hyung Jun Kim, Woong Nam, In Ho Cha

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC. Methods. We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival. Results. IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predictive factors for OSCC. Multivariate analysis showed that IMP3 expression was an independent prognostic indicator for OSCC. Conclusions. IMP3 expression was related to various clinicopathologic factors. IMP3 expression was an independent prognostic factor in patients with OSCC.

Original language	English
Pages (from-to)	368-374
Number of pages	7
Journal	Head and Neck
Volume	33
Issue number	3
DOIs	https://doi.org/10.1002/hed.21457
Publication status	Published - 2011 Mar

Bibliographical note

Funding Information:
This study was supported by project grants from the Wellcome Trust and the European Union. Some of these data were presented orally at the 1999 meeting of the European Association for the Study of Diabetes. We thank Ms. Lynda Stevens, statistician at University College (London) for assistance with the breakpoint analysis, Ms. Sue Manley from the Radcliffe Infirmary (Oxford) and Ms. Suky Sankaralingham for the standardization of follow-up HbA 1c performed by the London method to the DCCT method, and Mr. Gary John from St. Bartholomew's Hospital (London) for baseline standardization. We would also like to thank all staff and patients who took part in the study.

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hed.21457

Cite this

@article{0a851641a8414aa2a03c7b4c1f005074,

title = "Insulin-like growth factor II mRNA-binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma",

abstract = "Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC. Methods. We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival. Results. IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predictive factors for OSCC. Multivariate analysis showed that IMP3 expression was an independent prognostic indicator for OSCC. Conclusions. IMP3 expression was related to various clinicopathologic factors. IMP3 expression was an independent prognostic factor in patients with OSCC.",

author = "Shengjin Li and Jeongdan Cha and Jin Kim and Kim, {Ki Yeol} and Kim, {Hyung Jun} and Woong Nam and Cha, {In Ho}",

note = "Funding Information: This study was supported by project grants from the Wellcome Trust and the European Union. Some of these data were presented orally at the 1999 meeting of the European Association for the Study of Diabetes. We thank Ms. Lynda Stevens, statistician at University College (London) for assistance with the breakpoint analysis, Ms. Sue Manley from the Radcliffe Infirmary (Oxford) and Ms. Suky Sankaralingham for the standardization of follow-up HbA 1c performed by the London method to the DCCT method, and Mr. Gary John from St. Bartholomew's Hospital (London) for baseline standardization. We would also like to thank all staff and patients who took part in the study.",

year = "2011",

month = mar,

doi = "10.1002/hed.21457",

language = "English",

volume = "33",

pages = "368--374",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Insulin-like growth factor II mRNA-binding protein 3

T2 - A novel prognostic biomarker for oral squamous cell carcinoma

AU - Li, Shengjin

AU - Cha, Jeongdan

AU - Kim, Jin

AU - Kim, Ki Yeol

AU - Kim, Hyung Jun

AU - Nam, Woong

AU - Cha, In Ho

N1 - Funding Information: This study was supported by project grants from the Wellcome Trust and the European Union. Some of these data were presented orally at the 1999 meeting of the European Association for the Study of Diabetes. We thank Ms. Lynda Stevens, statistician at University College (London) for assistance with the breakpoint analysis, Ms. Sue Manley from the Radcliffe Infirmary (Oxford) and Ms. Suky Sankaralingham for the standardization of follow-up HbA 1c performed by the London method to the DCCT method, and Mr. Gary John from St. Bartholomew's Hospital (London) for baseline standardization. We would also like to thank all staff and patients who took part in the study.

PY - 2011/3

Y1 - 2011/3

N2 - Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC. Methods. We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival. Results. IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predictive factors for OSCC. Multivariate analysis showed that IMP3 expression was an independent prognostic indicator for OSCC. Conclusions. IMP3 expression was related to various clinicopathologic factors. IMP3 expression was an independent prognostic factor in patients with OSCC.

AB - Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC. Methods. We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival. Results. IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predictive factors for OSCC. Multivariate analysis showed that IMP3 expression was an independent prognostic indicator for OSCC. Conclusions. IMP3 expression was related to various clinicopathologic factors. IMP3 expression was an independent prognostic factor in patients with OSCC.

UR - http://www.scopus.com/inward/record.url?scp=79951712579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951712579&partnerID=8YFLogxK

U2 - 10.1002/hed.21457

DO - 10.1002/hed.21457

M3 - Article

C2 - 20652886

AN - SCOPUS:79951712579

SN - 1043-3074

VL - 33

SP - 368

EP - 374

JO - Head and Neck

JF - Head and Neck

IS - 3

ER -

Insulin-like growth factor II mRNA-binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this